Reactivity of ferritin and the structure of ferritin-derived ferrihydrite

• Published in: Biochimica et biophysica acta Vol. 1800; no. 8; pp. 871 - 885
• Main Authors: Michel, F. Marc, Hosein, Hazel-Ann, Hausner, Douglas B., Debnath, Sudeep, Parise, John B., Strongin, Daniel R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2010
• Subjects: Animals; Atomic arrangements; Ferric Compounds - chemical synthesis; Ferric Compounds - chemistry; Ferric Compounds - metabolism; Ferrihydrite; Ferrihydrite reactivity; Ferritin; Ferritins - chemistry; Ferritins - metabolism; Humans; Hydroxides - chemistry; Hydroxides - metabolism; Models, Biological; Models, Molecular; Oxidation-Reduction; Protein Conformation; Reconstituted; Structural topology; Ferrihydrite; Structural topology; Atomic arrangements; Ferrihydrite reactivity; Reconstituted; Ferritin
• ISSN: 0304-4165; 0006-3002; 1872-8006
• DOI: 10.1016/j.bbagen.2010.05.007

In nature or in the laboratory, the roughly spherical interior of the ferritin protein is well suited for the formation and storage of a variety of nanosized metal oxy-hydroxide compounds which hold promise for a range of applications. However, the linkages between ferritin reactivity and the structure and physicochemical properties of the nanoparticle core, either native or reconstituted, remain only partly understood. Here we review studies, including those from our laboratory, which have investigated the structure of ferritin-derived ferrihydrite and reactivity of ferritin, both native and reconstituted. Selected proposed structure models for ferrihydrite are discussed along with the structural and genetic relationships that exist among several different forms of ferrihydrite. With regard to reactivity, the review will emphasize studies that have investigated the (photo)reactivity of ferritin and ferritin-derived materials with environmentally relevant gaseous and aqueous species. The inorganic core formed from apoferritin reconstituted with varied amounts of Fe has the same structural topology as the inorganically derived ferrihydrite that is an important component of many environmental and soil systems. Reactivity of ferritin toward aqueous species resulting from the photoexcitation of the inorganic core of the protein shows promise for driving redox reactions relevant to environmental chemistry. Ferritin-derived ferrihydrite is effectively maintained in a relatively unaggregated state, which improves reactivity and opens the possibility of future applications in environmental remediation. Advances in our understanding of the structure, composition, and disorder in synthetic, inorganically derived ferrihydrite are shedding new light on the reactivity and stability of ferrihydrite derived artificially from ferritin.