Longitudinally extensive transverse myelitis preceding primary central nervous system lymphoma: Spinal sentinel neuroinflammation

• Published in: The journal of spinal cord medicine Vol. 46; no. 3; pp. 521 - 524
• Main Authors: Ser, Merve Hazal, Güleç, Bade, Salihoğlu, Ayşe, Uygunoğlu, Uğur
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 04.05.2023
• Subjects: Aged; Case Report; Central Nervous System; Female; Humans; Lymphoma - complications; Lymphoma - diagnosis; Magnetic Resonance Imaging; Myelitis, Transverse - diagnosis; Myelitis, Transverse - etiology; Neuroinflammatory Diseases; Spinal Cord Injuries - complications; Primary central nervous system lymphoma; Longitudinally extensive transverse myelitis; Sentinel neuroinflammation; Sentinel demyelination
• ISSN: 1079-0268; 2045-7723; 2045-7723
• DOI: 10.1080/10790268.2022.2087137

65-year-old female diagnosed with longitudinally extensive transverse myelitis. She had excellent response to immunotherapy despite her atypical features, and her spinal lesion was fully recovered in the second month of the treatment. Nine months after, she was diagnosed with primary cerebral central nervous system lymphoma while there was no recurrence of the spinal cord lesion as her most recent follow-up visit being 2 years after the LETM. Spinal sentinel neuroinflammation preceding primary central nervous system lymphoma might represent a valuable etiology in the differentials of LETM, as illustrated here.