IFN-stimulated Genes and Non–Type 2 Inflammation. New Pathway or Red Herring?

• Published in: American journal of respiratory and critical care medicine Vol. 197; no. 3; pp. 277 - 278
• Main Authors: Sharma, Sunita, Holguin, Fernando
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.02.2018
• Subjects: Animals; Asthma; Cytokines; Endoplasmic reticulum; Endoplasmic Reticulum Stress; Gene Expression; Genomes; Inflammation; Pathogenesis
• ISSN: 1073-449X; 1535-4970; 1535-4970
• DOI: 10.1164/rccm.201710-2144ED

Using RNA-sequencing data from airway epithelial cells of subjects with mild asthma and healthy control subjects, the authors confirmed previous analyses in which differential expression of known T2 genes was identified. Furthermore, the individuals who were identified as T1-high or T2-low based on this weighted gene coexpression network analysis were the youngest subjects, had the lowest fractional exhaled nitric oxide and highest quality-of-life scores, and represent a distinct asthma endotype (9). [...]the lack of association between the viral genome and ISGs should be interpreted with caution. Role of C/EBP homologous protein and endoplasmic reticulum stress in asthma exacerbation by regulating the IL-4/signal transducer and activator of transcription 6/transcription factor EC/IL-4 receptor a positive feedback loop in M2 macrophages.