Levels for Pyribenzamine and Benadryl in blood and urine following a single orally administered dose

1. 1. Blood levels and urinary excretion of Benadryl and Pyribenzamine, respectively, were determined in each of ten subjects following a single dose of 400 milligrams. 2. 2. Values in the blood for Benadryl began to rise within sixty minutes and reached an average peak of 1.07 micrograms per cubic...

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Published inThe Journal of allergy Vol. 19; no. 4; pp. 251 - 255
Main Authors McGavack, Thomas H., Drekter, I.J., Schutzer, Seymour, Heisler, Alexander
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.1948
Subjects
Body Fluids
Diphenhydramine - analysis
Histamine Antagonists
OldMedline
Tripelennamine
HISTAMINE/antagonist
BENADRYL/determination
PYRIBENZAMINE
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ISSN0021-8707
DOI10.1016/0021-8707(48)90062-8

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Summary:1. 1. Blood levels and urinary excretion of Benadryl and Pyribenzamine, respectively, were determined in each of ten subjects following a single dose of 400 milligrams. 2. 2. Values in the blood for Benadryl began to rise within sixty minutes and reached an average peak of 1.07 micrograms per cubic centimeter between 90 and 120 minutes. With Pyribenzamine an appreciable rise was first evident at 120 minutes and the trend was still upward at 180 minutes. 3. 3. Within the first twenty-four hours 46.0 and 20.1 per cent of the ingested Benadryl and Pyribenzamine, respectively, were excreted in the urine.
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ISSN:0021-8707
DOI:10.1016/0021-8707(48)90062-8