A simple method for “reference range” estimation from routine laboratory data

A simplified method is presented to estimate reference ranges from hospital laboratory data. It is based on a combination of graphical estimation of relative sizes of normal and abnormal populations and the “mode-center” concept in which the mode of the total population centers on the 50% cumulative...

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Bibliographic Details
Published inClinical biochemistry Vol. 9; no. 4; pp. 198 - 202
Main Authors Chu, Samuel Y., Cheung, P., Turkington, V.E.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.1976
Subjects
Blood Urea Nitrogen
Calcium - blood
Chemistry, Clinical
Evaluation Studies as Topic
Humans
Mathematics
Methods
Population
Quality Control
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ISSN0009-9120
1873-2933
DOI10.1016/S0009-9120(76)80057-4

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Summary:A simplified method is presented to estimate reference ranges from hospital laboratory data. It is based on a combination of graphical estimation of relative sizes of normal and abnormal populations and the “mode-center” concept in which the mode of the total population centers on the 50% cumulative frequency of the normal population. This method can be applied to determine reference ranges even though the data source contains abnormally high and/or low values. The reference ranges obtained for BUN and calcium from in-patient and out-patient sources by this method were found to be similar to those reported for “healthy” subjects.
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ISSN:0009-9120
1873-2933
DOI:10.1016/S0009-9120(76)80057-4