Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection With accumulation of mutations in a patient with poorly controlled Human Immunodeficiency Virus infection

Abstract A 22-year-old woman with uncontrolled advanced human immunodeficiency virus (HIV) infection was persistently infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) beta variant for 9 months, the virus accumulating >20 additional mutations. Antiretroviral therapy suppr...

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Published inClinical infectious diseases Vol. 76; no. 3; pp. e522 - e525
Main Authors Maponga, Tongai G, Jeffries, Montenique, Tegally, Houriiyah, Sutherland, Andrew, Wilkinson, Eduan, Lessells, Richard J, Msomi, Nokukhanya, van Zyl, Gert, de Oliveira, Tulio, Preiser, Wolfgang
Format Journal Article
LanguageEnglish
Published US Oxford University Press 08.02.2023
Subjects
Adult
COVID-19
Female
HIV Infections - complications
HIV Infections - drug therapy
Humans
Mutation
SARS-CoV-2 - genetics
Young Adult
SARS-CoV-2
uncontrolled HIV infection
immunocompromised
persistent infection
antiretroviral therapy
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ISSN1058-4838
1537-6591
1537-6591
DOI10.1093/cid/ciac548

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Summary:Abstract A 22-year-old woman with uncontrolled advanced human immunodeficiency virus (HIV) infection was persistently infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) beta variant for 9 months, the virus accumulating >20 additional mutations. Antiretroviral therapy suppressed HIV and cleared SARS-CoV-2 within 6 to 9 weeks. Increased vigilance is warranted to benefit affected individuals and prevent the emergence of novel SARS-CoV-2 variants.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:1058-4838
1537-6591
1537-6591
DOI:10.1093/cid/ciac548