The Role of Metallodrugs in Cellular Senescence

• Published in: European journal of inorganic chemistry Vol. 26; no. 4
• Main Authors: Redrado, Marta, Fernández‐Moreira, Vanesa
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.02.2023
• Subjects: Cancer; Chemotherapy; Coordination compounds; Drug discovery; Inorganic chemistry; Metal complexes; Nanoparticles; Organic chemistry; Pro-senescence therapy; Senescence; Senotherapy
• ISSN: 1434-1948; 1099-0682
• DOI: 10.1002/ejic.202200593

Delivering alternative strategies to deal with cancer is a huge milestone in research. Cancer cells can give a senescence response as consequence of cellular stress or external stimuli such as the use of chemotherapies, which could end up eventually in cancer relapse. Controlling cellular senescence will surely open new cancer treatment approaches. Cancer senescence induction can be used as an added timeframe to look for alternative treatments and senolytic drugs to avoid cancer relapse destroying the senescent cells (SnCs). Within cancer senescence research, metal complexes are underdeveloped in comparison with that of organic molecules or nanoparticles. Herein, we highlight the scarce investigation performed with metal complexes in the field of senescence and how a great input on them could be a huge step towards the search of alternative cancer treatments. Senescence is a double‐edged sword that needs to be tackled thoroughly in the field of cancer and aging diseases. This perspective highlights the great possibilities of using senotherapy as a new approach for dealing with cancer and underlines the little research on metal‐based drugs in cellular senescence. The scarce examples found reflect the infancy stage of this research.