Association of rs7260002 of chorionic gonadotrophin β5 with idiopathic recurrent spontaneous abortion in Chinese population

• Published in: Journal of assisted reproduction and genetics Vol. 31; no. 11; pp. 1497 - 1500
• Main Authors: Sun, Yong, Ji, Xuan
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.11.2014
• Subjects: Abortion, Habitual - genetics; Asian Continental Ancestry Group - genetics; Chorionic Gonadotropin, beta Subunit, Human - genetics; Female; Genetic Association Studies; Genetics; Genotype; Gynecology; Human Genetics; Humans; Medicine; Medicine & Public Health; Polymorphism, Single Nucleotide; Regression Analysis; Reproductive Medicine; Genetic association study; Genotype; Recurrent spontaneous abortion; Chorionic gonadotrophin β5
• ISSN: 1058-0468; 1573-7330; 1573-7330
• DOI: 10.1007/s10815-014-0321-1

Purpose Low levels of serum hCG during the first trimester is regarded as a predictor of miscarriage. This study was designed to examine whether variance in chorionic gonadotrophin β5 ( Cgb5 ) gene confers risk to recurrent spontaneous abortions (RSA) in Chinese women. Methods We recruited a total of 454 RSA subjects and 460 controls from our medical center between the years 2010 to 2013. rs7260002, which resides in the promoter region of Cgb5 , was genotyped through direct sequencing. Results The carriers with the minor allele of rs7260002 had reduced risk of RSA ( P  = 0.018; P adjusted = 0.032; OR: 0.76; 95 % CI: 0.61–0.96). Genotype frequency was further analyzed under additive, recessive, and dominant models. Significant differences between the RSA subjects and controls were detected under additive and recessive models (P additive = 0.040; P recessive = 0.010). Conclusions The current study identified a protective allele of the Cgb5 gene against RSA. Functional studies are required to elucidate the effect of the identified SNP on CGB expression and HCG hormone activity.