Lead Generation: Sowing the Seeds for Future Success

Lead generation and the associated hit-to-lead process are key strategic elements in modern pharmaceutical research, and most companies have implemented this concept. Efficient lead generation is one of the main attempts to reduce the high attrition rates observed along the drug discovery process by...

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Bibliographic Details
Published inChimia Vol. 58; no. 9
Main Authors Konrad H. Bleicher, Matthias Nettekoven, Jens-Uwe Peters, René Wyler
Format Journal Article
LanguageEnglish
Published Swiss Chemical Society 01.09.2004
Subjects
Lead generation
Lead series
Parallel synthesis
Privileged structures
Targeted libraries
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ISSN0009-4293
2673-2424
DOI10.2533/000942904777677542

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Summary:Lead generation and the associated hit-to-lead process are key strategic elements in modern pharmaceutical research, and most companies have implemented this concept. Efficient lead generation is one of the main attempts to reduce the high attrition rates observed along the drug discovery process by focussing on the early developmental phases. The level of integration of the lead generation activities within the discovery organization, the flexibility in assessing and implementing new chemistries and new technologies, the high-quality standards set for the identification of the best possible chemical lead series will ultimately determine the future success in discovering new medicines.
ISSN:0009-4293
2673-2424
DOI:10.2533/000942904777677542