Inverse Association of High-Density Lipoprotein Cholesterol Concentration with Muscle Mass in Children

• Published in: Childhood obesity Vol. 15; no. 7; pp. 476 - 484
• Main Authors: Duran, Ibrahim, Martakis, Kyriakos, Schafmeyer, Leonie, Jackels, Miriam, Rehberg, Mirko, Schoenau, Eckhard
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.10.2019
• Subjects: Adults; Age; Cardiovascular disease; childhood obesity; Cholesterol; Datasets; dual-energy X-ray absorptiometry; Ethnicity; Exercise; fat mass index; Fitness training programs; high density lipoprotein cholesterol; Lipids; Lipoproteins; Medical laboratories; muscle tissues; Musculoskeletal system; National Health and Nutrition Examination Survey; Nutrition; Obesity; Physical fitness; risk factors; Student athletes; Studies; Teenagers; United States > US; muscle mass; children; reference centiles; fat mass; HDL cholesterol
• ISSN: 2153-2168; 2153-2176; 2153-2176
• DOI: 10.1089/chi.2019.0122

Obesity was often associated with low high-density lipoprotein (HDL) cholesterol concentration, which is an established cardiovascular risk factor. To evaluate the association of HDL-cholesterol concentration with fat and muscle mass in children and adolescents. Data of the National Health and Nutrition Examination Survey (1999-2004) were used to estimate fat and muscle mass by dual-energy X-ray absorptiometry (DXA) of the participants who had also an examination of their lipid profiles. Fat mass was assessed by DXA-determined fat mass index (FMI). Muscle mass was operationalized by appendicular lean mass index (LMI). Low HDL-cholesterol concentration was defined as <40 mg/dL. For the evaluation of the association of HDL-cholesterol concentration with FMI and LMI Z-scores, the data of 6288 children and adolescents (age 8-19 years) (2535 females) were eligible. In the study population, the prevalence of low HDL-cholesterol concentration increased with rising FMI and appendicular LMI Z-scores. The study results suggested that there is a counterintuitive, inverse association of muscle mass and HDL-cholesterol concentration.