α-glucosidase inhibitory activities of myricetin in animal models of diabetes mellitus

• Published in: Food science and biotechnology Vol. 24; no. 5; pp. 1897 - 1900
• Main Authors: Kang, Soo-Jeong, Park, Jung-Han Yoon, Choi, Ha-Neul, Kim, Jung-In
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society of Food Science and Technology 01.10.2015; 한국식품과학회
• Subjects: acarbose; alpha-glucosidase; animal disease models; blood serum; Chemistry; Chemistry and Materials Science; diabetes mellitus; diet; Food Science; glucose; glycohemoglobin; hyperglycemia; mice; myricetin; Nutrition; rats; Research Note; small intestine; starch; 식품과학; mouse; α-glucosidase; glucose; myricetin; glycated hemoglobin
• ISSN: 1226-7708; 2092-6456
• DOI: 10.1007/s10068-015-0249-y

The α-glucosidase inhibitory activity of myricetin in vivo was investigated. Streptozotocininduced diabetic rats were administered a starch solution (1 g/kg) with and without myricetin (100 mg/kg) or acarbose (40 mg/kg) after an overnight fast. Myricetin and acarbose alleviated postprandial hyperglycemia conditions, compared with untreated rats. Consumption of 0.08% myricetin or 0.03% acarbose in the diet for 7 weeks significantly ( p <0.05) reduced the serum fasting glucose, blood glycated hemoglobin, and maltase activities of the small intestine in db/db mice, compared with controls. Myricetin can be beneficial for control of hyperglycemia in diabetes mellitus partly via inhibition of the a-glucosidase activity.