Exosomal LncRNAs and hepatocellular Carcinoma: From basic research to clinical practice

[Display omitted] Hepatocellular carcinoma (HCC) is the most common primary liver cancer with poor prognosis. The incidences of HCC and HCC-related deaths have increased over the last several decades. However, the treatment options for advanced HCC are very limited. Long noncoding RNAs (lncRNAs) wra...

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Published inBiochemical pharmacology Vol. 200; p. 115032
Main Authors Li, Liangyun, Bi, Yihui, Diao, Shaoxi, Li, Xiaofeng, Yuan, Tong, Xu, Tao, Huang, Cheng, Li, Jun
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 01.06.2022
Subjects
Exosomes
Hepatocellular carcinoma
LncRNAs
Therapy
Therapy
ceRNA
NAFLD
lncRNA
Hepatocellular carcinoma
mRNA
Exosomes
ncRNAs
ctDNA
TAMs
MREs
RNA SEQ
miRNA
HBV
CTCs
LncRNAs
qRT-PCR
HCC
EMT
TME
IL-6
PPIs
IPSCs
LC
HCV
HSCs
CHB
HUVECs
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ISSN0006-2952
1873-2968
1873-2968
DOI10.1016/j.bcp.2022.115032

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Summary:[Display omitted] Hepatocellular carcinoma (HCC) is the most common primary liver cancer with poor prognosis. The incidences of HCC and HCC-related deaths have increased over the last several decades. However, the treatment options for advanced HCC are very limited. Long noncoding RNAs (lncRNAs) wrapped in exosomes can change the expression of their target genes in recipient cells, thereby regulating the behavior of recipient cells. Increasing evidence has demonstrated that there is a correlation between the activation of exosomal lncRNAs and the development of HCC. In this review article, we highlighted the functions of exosomal lncRNAs in the development of HCC, showing that exosomal lncRNAs play a vital role in the growth and progression of HCC and are targets for HCC.
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ISSN:0006-2952
1873-2968
1873-2968
DOI:10.1016/j.bcp.2022.115032