Paper-Based Fluorescence Chemosensors for Metal Ion Detection in Biological and Environmental Samples

• Published in: Biochip journal Vol. 15; no. 3; pp. 216 - 232
• Main Authors: Sivakumar, Rajamanickam, Lee, Nae Yoon
• Format: Journal Article
• Language: English
• Published: Seoul The Korean BioChip Society (KBCS) 01.09.2021; Springer Nature B.V; 한국바이오칩학회
• Subjects: Aluminum; Binding sites; Biomedical Engineering and Bioengineering; Biotechnology; Charge transfer; Chelation; Chemical sensors; Chemistry; Chemistry and Materials Science; Chemoreceptors; Chromatography; Electron transfer; Energy; Energy charge; Energy transfer; Fluorescence; Fluorescence resonance energy transfer; Ion detectors; Medical imaging; Metal ions; Nanoparticles; Quantum dots; Review Article; Rhodamine; Scientific imaging; Sensors; Target detection; 생물공학; Fluorescence chemosensor; Paper strip; Environmental monitoring; Metal ions
• ISSN: 1976-0280; 2092-7843
• DOI: 10.1007/s13206-021-00026-z

The recognition and detection of metal ions present in biological and environmental samples have attracted great attention in recent years. Various analytical techniques are used to detect metal ions. Among these, the fluorescence technique is among the emerging methods because of its simplicity, selectivity, and applicability to bioimaging. Thus, this review particularly explores paper-based fluorescence chemosensors involved in metal ion detection. Significantly, the first section addresses relevant research on metal ion detection involving various techniques. In the second section, several sensing strategies such as photoinduced electron transfer, fluorescence resonance energy transfer, intramolecular charge transfer, chelation enhanced fluorescence, excited-state intramolecular proton transfer, and aggregation-induced emission for the detection of target metal ions (aluminum, copper, iron, lead, mercury, and zinc) are investigated. The third section particularly discusses the role of fluorescence sensor materials (e.g., fluorescein, rhodamine, naphthalimide, BODIPY, carbon dots, quantum dots) involved in the detection processes and their advantages and limitations. Overall, this article reviews 90 research articles on paper-based fluorescence chemosensors for metal ion detection published until 2021.