Bone marrow harvest in donors with anaemia

• Published in: Vox sanguinis Vol. 113; no. 8; pp. 795 - 802
• Main Authors: Bartnik, Krzysztof, Pruszczyk, Katarzyna, Skwierawska, Kamila, Król, Małgorzata, Płachta, Milena, Moskowicz, Albert, Zakrzewski, Tomasz, Urbanowska, Elżbieta, Jędrzejczak, Wiesław Wiktor, Snarski, Emilian
• Format: Journal Article
• Language: English
• Published: England S. Karger AG 01.11.2018
• Subjects: Adult; anaemia prior to procedure; Anemia; Anemia - blood; Blood Donors; Blood transfusion; Body weight; Bone marrow; Bone Marrow Cells - chemistry; Bone marrow transplantation; Bone Marrow Transplantation - methods; Bone Marrow Transplantation - standards; Donor Selection - methods; Donor Selection - standards; Female; Guidelines; Hematopoietic stem cells; Hemoglobin; Hemoglobins - analysis; Humans; Middle Aged; Stem cell transplantation; Stem cells; Transfusion; Transplantation; unrelated donors; anaemia prior to procedure; unrelated donors
• ISSN: 0042-9007; 1423-0410; 1423-0410
• DOI: 10.1111/vox.12709

Background Bone marrow harvest (BMH) for haematopoietic stem cell transplantation is a well‐established procedure. The guidelines of World Marrow Donor Association provide information on donor selection. However, some of the guidelines regarding donors with anaemia prior to harvest lack in supporting data from clinical studies. With this study, we aimed to provide such data. Material and Methods In this retrospective, single‐centre study, we analysed the interplay between haemoglobin levels and BMH and BMH impact on haemoglobin levels in a cohort of 149 unrelated BM donors, including 13 subjects with mild anaemia. Results The BMH led to significantly lower decrease in haemoglobin levels in donors with anaemia than in control group (1·79 g/dl vs. 2·56 g/dl, P < 0·0001). The following parameters: BMH volume (ml), BMH volume/donor body weight (ml/kg), total nucleated cells (TNC) in product (×108) and TNC/kg recipient body weight in product (×108/kg) did not differ significantly between those two analysed groups (P > 0·05). Median BM volume harvested from anaemic donors was 16·34 ml/kg; none of them required blood transfusion after BMH. Conclusion Mild anaemia prior to BMH does not significantly impact the collection results. The BMH is safe and feasible in donors with mild anaemia.