Outcome of older patients with acute myeloid leukemia in first relapse

• Published in: American journal of hematology Vol. 88; no. 9; pp. 758 - 764
• Main Authors: Sarkozy, Clémentine, Gardin, Claude, Gachard, Nathalie, Merabet, Fathia, Turlure, Pascal, Malfuson, Jean‐Valère, Pautas, Cécile, Micol, Jean‐Baptiste, Thomas, Xavier, Quesnel, Bruno, Celli‐Lebras, Karine, Preudhomme, Claude, Terré, Christine, Fenaux, Pierre, Chevret, Sylvie, Castaigne, Sylvie, Dombret, Hervé
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.09.2013
• Subjects: Age Factors; Aged; Aminoglycosides - administration & dosage; Antibodies, Monoclonal, Humanized - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cytarabine - administration & dosage; Female; Hematology; Humans; Karyotyping; Leukemia, Myeloid, Acute - mortality; Leukemia, Myeloid, Acute - therapy; Male; Medical research; Medical treatment; Middle Aged; Recurrence; Remission Induction - methods; Salvage Therapy - methods; Survival Analysis; Treatment Outcome
• ISSN: 0361-8609; 1096-8652; 1096-8652
• DOI: 10.1002/ajh.23498

To provide data for future drug evaluation, we analyzed the outcome of 393 patients aged 50 years or older (median, 64 years) with AML in first relapse after treatment in recent ALFA trials. Salvage options were retrospectively classified as follows: best supportive care (BSC), low‐dose cytarabine (LDAC), gemtuzumab ozogamicin (GO), intensive chemotherapy (ICT), or ICT combined with GO. Second complete remission (CR2) rate was 31% and median post‐relapse survival was 6.8 months (0, 17, 42.5, 53, and 80% and 3.2, 5.6, 8.9, 9, and 19.8 months in BSC, LDAC, GO, ICT, and ICT + GO subsets, respectively). Age, performance status, WBC, CR1 duration, and favorable AML karyotype, but not other cytogenetic or molecular features, influenced post‐relapse outcome. Multivariate adjustment and propensity score matching showed that intensive salvage (ICT/ICT+GO/GO versus LDAC/BSC) was associated with longer post‐relapse survival, at least in patients with CR1 duration ≥12 months (P = 0.001 and 0.0005, respectively). Of interest, GO appeared to be as effective as standard ICT, and ICT + GO combination more effective than standard ICT. In conclusion, older patients with CR1 duration ≥12 months appeared to benefit from intensive salvage and results observed with GO‐containing salvage suggest that GO combination studies should be actively pursued in this setting. Am. J. Hematol. 88:758–764, 2013. © 2013 Wiley Periodicals, Inc.