Respiratory virus infections after allogeneic stem cell transplantation: Current understanding, knowledge gaps, and recent advances

• Published in: Transplant infectious disease Vol. 25; no. S1; pp. e14117 - n/a
• Main Authors: Piñana, Jose L., Pérez, Ariadna, Chorão, Pedro, Guerreiro, Manuel, García‐Cadenas, Irene, Solano, Carlos, Martino, Rodrigo, Navarro, David
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.11.2023
• Subjects: adenovirus; allogeneic stem cell transplantation; Allografts; community acquired respiratory virus (CARV); COVID-19; COVID-19 - epidemiology; Hematopoietic Stem Cell Transplantation - adverse effects; Hematopoietic stem cells; human adenovirus; human bocavirus; human metapneumovirus; human parainfluenza virus; human seasonal coronavirus; Humans; influenza virus; Pandemics; Respiratory Tract Infections - epidemiology; respiratory virus; rhinovirus; SARS‐CoV‐2; Severe acute respiratory syndrome coronavirus 2; Stem cell transplantation; Stem cells; Transplantation; vaccines.VRS; Viral diseases; Viruses; respiratory virus; rhinovirus; COVID-19; community acquired respiratory virus (CARV); SARS-CoV-2; allogeneic stem cell transplantation; vaccines.VRS; adenovirus; influenza virus; human adenovirus; human parainfluenza virus; human metapneumovirus; human seasonal coronavirus; human bocavirus
• ISSN: 1398-2273; 1399-3062; 1399-3062
• DOI: 10.1111/tid.14117

Before the COVID‐19 pandemic, common community‐acquired seasonal respiratory viruses (CARVs) were a significant threat to the health and well‐being of allogeneic hematopoietic cell transplant (allo‐HCT) recipients, often resulting in severe illness and even death. The pandemic has further highlighted the significant risk that immunosuppressed patients, including allo‐HCT recipients, face when infected with SARS‐CoV‐2. As preventive transmission measures are relaxed and CARVs circulate again among the community, including in allo‐HSCT recipients, it is crucial to understand the current state of knowledge, gaps, and recent advances regarding CARV infection in allo‐HCT recipients. Urgent research is needed to identify seasonal respiratory viruses as potential drivers for future pandemics.