Lipidic nanomaterials to deliver natural compounds against cancer: a review

• Published in: Environmental chemistry letters Vol. 18; no. 6; pp. 1803 - 1812
• Main Authors: Chaudhari, Vishal Sharad, Murty, Upadhyayula Suryanarayana, Banerjee, Subham
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.11.2020; Springer Nature B.V
• Subjects: Analytical Chemistry; Biocompatibility; Cancer; Drug delivery; drugs; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; environmental science; Geochemistry; Lipids; Liposomes; Metabolism; Micelles; Nanomaterials; Nanoparticles; Nanotechnology; Permeability; Pharmacodynamics; Pharmacology; Photosensitivity; Pollution; Review; solubility; Natural products; Improved delivery; Lipid nanoconstructs; Cancer
• ISSN: 1610-3653; 1610-3661
• DOI: 10.1007/s10311-020-01042-5

Many diseases such as cancer are cured by natural substances, yet practical applications are limited by low pharmacodynamics due to poor solubility and permeability, photosensitivity, chemical instability, and first-pass metabolism. These issues are partly solved by nanotechnology. Here, we review briefly lipid-based nanomaterials for drug delivery. Indeed, lipid nanoconstructs allow active and passive targeting, biocompatibility, improved safety, and efficacy. Lipid nanoconstructs include both vesicular- and particulate-based systems such as liposomes, lipid micelles, solid lipid nanoparticles, and nanostructured lipid carriers.