Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community

• Published in: Movement disorders Vol. 24; no. 2; pp. 290 - 292
• Main Authors: Mehta, Prachi, Mellick, George D., Rowe, Dominic B., Halliday, Glenda M., Jones, Michael M., Manwaring, Neil, Vandebona, Himesha, Silburn, Peter A., Wang, Jie Jin, Mitchell, Paul, Sue, Carolyn M.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 30.01.2009; Wiley
• Subjects: Age of Onset; Aged; Aged, 80 and over; Australia - epidemiology; Biological and medical sciences; Case-Control Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; DNA, Mitochondrial - classification; DNA, Mitochondrial - genetics; Europe - ethnology; European Continental Ancestry Group - genetics; Female; Genetic Predisposition to Disease; Haplotypes - genetics; Humans; Male; Medical sciences; Middle Aged; mitochondrial DNA haplogroups; Neurology; Parkinson Disease - epidemiology; Parkinson Disease - ethnology; Parkinson Disease - genetics; Parkinson's disease; Polymorphism, Single Nucleotide; prevalence; Risk; Australia; Europe; Prevention; mitochondrial DNA haplogroups; Nervous system diseases; Prevalence; Parkinson's disease; Central nervous system disease; Parkinson disease; Degenerative disease; Mitochondrial DNA; Cerebral disorder; Extrapyramidal syndrome
• ISSN: 0885-3185; 1531-8257; 1531-8257
• DOI: 10.1002/mds.22389

MtDNA haplogroups J and K have been associated with a decreased risk of developing Parkinson's disease (PD). To confirm this finding, we compared the distribution of mtDNA haplogroups J and K in a large sample of Australian patients with PD (n = 890) to population‐based controls (n = 3,491). We assigned subjects to haplogroups J or K using standard PCR/RFLP techniques. Of the 890 subjects with PD, 10.6% were haplogroup J (95% CI 8.6–12.8, n = 94) and 7.1% were haplogroup K (95% CI 5.5–8.9, n = 63). In our controls, 10.2% belonged to haplogroup J (95% CI 9.2–11.2, n = 356), and 7.8% were in haplogroup K (95% CI 6.9–8.7, n = 272). There was no significant difference in the prevalence of mtDNA haplogroup J or K in PD patients compared to population‐based controls. Our findings indicate that mtDNA haplogroups J and K are not associated with a lower risk of PD. © 2008 Movement Disorder Society