Cryptococcal Disease in Diverse Hosts

• Published in: The New England journal of medicine Vol. 390; no. 17; pp. 1597 - 1610
• Main Authors: Meya, David B., Williamson, Peter R.
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 02.05.2024
• Subjects: Acquired immune deficiency syndrome; AIDS; Antifungal Agents - therapeutic use; Antigens, Fungal - blood; Antigens, Fungal - cerebrospinal fluid; Chemotherapy; Clinical deterioration; Cryptococcosis - diagnosis; Cryptococcosis - epidemiology; Cryptococcosis - immunology; Cryptococcosis - therapy; Cryptococcus - immunology; Cryptococcus - pathogenicity; Developing countries; Encephalitis; Flucytosine; Fungal Infections; Fungi; Global Health; HIV; HIV Infections - drug therapy; HIV Infections - immunology; Host-Pathogen Interactions - immunology; Human immunodeficiency virus; Humans; Immune reconstitution; Immune Reconstitution Inflammatory Syndrome - etiology; Immune system; Immunocompromised Host; Immunosuppression; Immunosuppressive agents; Immunosuppressive Agents - adverse effects; Immunotherapy; Infectious Disease; Inflammation; Intracranial Hypertension - etiology; Intracranial Hypertension - therapy; Kinases; LDCs; Meningitis; Meningitis, Cryptococcal - diagnosis; Meningitis, Cryptococcal - epidemiology; Meningitis, Cryptococcal - immunology; Meningitis, Cryptococcal - therapy; Mutation; Neurology; Neurosurgery; Pathogens; Patients; Risk Factors; Streptococcus infections; Virulence; France; United States > US; Africa
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMra2311057

Cryptococcus accounts for up to 180,000 deaths annually and 68% of HIV-related meningitis cases. The authors discuss diagnostic, preventive, and therapeutic strategies and the pathophysiological role of inflammatory syndromes.