BDNF Val66Met polymorphism is associated with unstable angina

• Published in: Clinica chimica acta Vol. 400; no. 1; pp. 3 - 7
• Main Authors: Jiang, Hong, Wang, Rong, Liu, Yan, Zhang, Yun, Chen, Zhe-Yu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2009
• Subjects: Angina, Unstable - blood; Angina, Unstable - complications; Angina, Unstable - genetics; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - blood; Brain-Derived Neurotrophic Factor - genetics; C-Reactive Protein - metabolism; Case-Control Studies; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - complications; Coronary Artery Disease - genetics; Female; High-sensitivity C-reactive protein; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Single nucleotide polymorphism; Unstable angina pectoris; High-sensitivity C-reactive protein; SAP; Brain-derived neurotrophic factor; BDNF; UAP; CAD; hsCRP; Single nucleotide polymorphism; Coronary artery disease; Unstable angina pectoris
• ISSN: 0009-8981; 1873-3492; 1873-3492
• DOI: 10.1016/j.cca.2008.10.017

Brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of coronary artery disease (CAD). The human BDNF Val66Met polymorphism has been shown to be associated with altered susceptibility to neuropsychiatric disorders. However it is unknown whether this polymorphism plays a role in cardiovascular disease. Genotyping of BDNF Val66Met polymorphism was carried out in 513 controls, 628 unstable angina pectoris (UAP) and 276 stable angina pectoris (SAP) patients. The plasma concentrations of BDNF and high-sensitivity C-reactive protein (hsCRP) were measured by ELISA. The general clinical data in patients and controls were obtained. There was a significant association between genotype and allele frequency of the BDNF Val66Met polymorphism and UAP (all P < 0.05). Multivariate logistic regression analysis revealed that the BDNF Met/Met genotype had a protective effect on the occurrence of UAP after controlling for known risk factors of CAD (OR 0.53, P = 0.005). Subjects with BDNF Met/Met genotype also had decreased plasma hsCRP levels compared with the Val carriers ( P < 0.01). The BDNF Met/Met genotype has a protective effect on the occurrence of UAP, which might in part be due to the decreased plasma hsCRP level in BDNF Met/Met carriers. To our knowledge, this is the first study that demonstrates the link between BDNF Val66Met polymorphism and CAD.