Process synthesis and optimization for the isolation and purification of paclitaxel from Taxus chinensis

Cavitation extraction, water/hexane washing, and cavitation precipitation-based process synthesis and optimization were performed for the isolation and purification of biomass-derived paclitaxel. The final purity, overall yield, and operating time were significantly improved when negative pressure c...

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Published inThe Korean journal of chemical engineering Vol. 39; no. 12; pp. 3389 - 3398
Main Authors Min, Hye-Su, Kim, Jin-Hyun
Format Journal Article
LanguageEnglish
Published New York Springer US 01.12.2022
Springer Nature B.V
한국화학공학회
Subjects
Biotechnology
Catalysis
Cavitation
Chemistry
Chemistry and Materials Science
Hexanes
Industrial Chemistry/Chemical Engineering
Materials Science
Optimization
Purity
Synthesis
Washing
Water purification
화학공학
Process Synthesis
Negative Pressure Cavitation
Extraction
Purification
Fractional Precipitation
Paclitaxel
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ISSN0256-1115
1975-7220
DOI10.1007/s11814-022-1261-6

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Summary:Cavitation extraction, water/hexane washing, and cavitation precipitation-based process synthesis and optimization were performed for the isolation and purification of biomass-derived paclitaxel. The final purity, overall yield, and operating time were significantly improved when negative pressure cavitation extraction was followed by sequential washing with water and hexane, adsorbent treatment, and negative pressure cavitation fractional precipitation using acetone-pentane and methanol-water. This procedure showed a purity and yield increase of 11.0–45.6% and 2.2–29.6%, respectively, and an operating time reduction of 56.2–98.3% compared to the traditional methods.
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ISSN:0256-1115
1975-7220
DOI:10.1007/s11814-022-1261-6