Edoxaban Antithrombotic Therapy for Atrial Fibrillation and Stable Coronary Artery Disease

• Published in: The New England journal of medicine Vol. 391; no. 22; pp. 2075 - 2086
• Main Authors: Cho, Min Soo, Kang, Do-Yoon, Ahn, Jung-Min, Yun, Sung-Cheol, Oh, Yong-Seog, Lee, Chang Hoon, Choi, Eue-Keun, Lee, Ji Hyun, Kwon, Chang Hee, Park, Gyung-Min, Choi, Hyung Oh, Park, Kyoung-Ha, Park, Kyoung-Min, Hwang, Jongmin, Yoo, Ki-Dong, Cho, Young-Rak, Kim, Ji Hyun, Hwang, Ki Won, Jin, Eun-Sun, Kwon, Osung, Kim, Ki-Hun, Park, Seung-Jung, Park, Duk-Woo, Nam, Gi-Byoung
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 05.12.2024
• Subjects: Acute coronary syndromes; Aged; Aged, 80 and over; Anticoagulants; Anticoagulation; Antiplatelet therapy; Arrhythmias; Atrial Fibrillation - complications; Atrial Fibrillation - drug therapy; Atrial Fibrillation - mortality; Bleeding; Cardiac arrhythmia; Cardiology; Cardiology General; Cardiovascular disease; Cerebral infarction; Clinical trials; Coronary artery disease; Coronary Artery Disease - complications; Coronary Artery Disease - drug therapy; Coronary Artery Disease - mortality; Coronary Disease; Coronary vessels; Defibrillators; Drug Therapy, Combination - adverse effects; Drug Therapy, Combination - methods; Embolism; Embolism - epidemiology; Embolism - etiology; Embolism - prevention & control; Embolisms; Factor Xa Inhibitors - administration & dosage; Factor Xa Inhibitors - adverse effects; Female; Fibrillation; Heart attacks; Heart diseases; Hemorrhage - chemically induced; Hemorrhage - epidemiology; Humans; Incidence; Ischemia; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Myocardial Infarction - epidemiology; Myocardial Infarction - etiology; Myocardial Infarction - prevention & control; Pacemakers; Patients; Pharmacists; Platelet Aggregation Inhibitors - administration & dosage; Platelet Aggregation Inhibitors - adverse effects; Pyridines - administration & dosage; Pyridines - adverse effects; Republic of Korea - epidemiology; Software; Stroke; Stroke - epidemiology; Stroke - etiology; Stroke - prevention & control; Thiazoles - administration & dosage; Thiazoles - adverse effects; Thromboembolism; Thrombosis; Treatment Outcome; Vein & artery diseases; Republic of Korea; South Korea
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa2407362

In this multicenter, randomized trial, edoxaban monotherapy led to a lower risk of net clinical adverse events at 12 months than dual antithrombotic therapy in patients with atrial fibrillation and stable coronary artery disease.