Oxidative dimerization of azoles via copper(II)/silver(I)-catalyzed CH homocoupling

When several azole derivatives such as imidazole, thiazole, and oxazole are treated with a catalyst system of copper(II)/silver(I) under oxygen atmosphere, oxidative dimerization at the CH bond of the 2-position takes place to afford the corresponding bisazoles up to 86% yield. When several azole de...

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Bibliographic Details
Published inTetrahedron letters Vol. 51; no. 5; pp. 850 - 852
Main Authors Monguchi, Daiki, Yamamura, Akira, Fujiwara, Taiki, Somete, Takashi, Mori, Atsunori
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 03.02.2010
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
FUNCTIONALIZATION
DIRECT AMINATION
DIRECT ARYLATION REACTIONS
COUPLING REACTION
ARYL HALIDES
ELECTROPHILIC SUBSTITUTION
HETEROAROMATIC-COMPOUNDS
DERIVATIVES
EFFICIENT
CATALYZED ARYLATION
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ISSN0040-4039
1873-3581
DOI10.1016/j.tetlet.2009.12.016

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Summary:When several azole derivatives such as imidazole, thiazole, and oxazole are treated with a catalyst system of copper(II)/silver(I) under oxygen atmosphere, oxidative dimerization at the CH bond of the 2-position takes place to afford the corresponding bisazoles up to 86% yield. When several azole derivatives such as imidazole, thiazole, and oxazole are treated with a catalyst system of copper(II)/silver(I) under oxygen atmosphere, oxidative dimerization at the CH bond of the 2-position takes place to afford the corresponding bisazoles up to 86% yield.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2009.12.016