Novel DNA fluorescence probes based on 2-thioxo-tetrahydro-4H-imidazol-4-ones: synthetic and biological studies

An efficient method for the liquid-phase synthesis of 3,5-disubstituted thiohydantoins has been developed. This new class of substituted thiohydantoins was tested as DNA fluorescence probes. Anthracene-substituted thiohydantoin undergoes a change in fluorescence in the presence of DNA. (C) 2011 Else...

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Published inTetrahedron letters Vol. 53; no. 1; pp. 51 - 53
Main Authors Majouga, Alexander G., Udina, Anna V., Beloglazkina, Elena K., Skvortsov, Dmitrii A., Zvereva, Maria I., Dontsova, Olga A., Zyk, Nikolay V., Zefirov, Nikolay S.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 04.01.2012
Subjects
Biological
chemical reactions
chemical structure
Chemistry
Chemistry, Organic
Deoxyribonucleic acid
DNA
Fluorescence
organic compounds
Physical Sciences
Science & Technology
synthesis
Synthesis (chemistry)
Tetrahedrons
DNA probes
Fluorescence
Thiohydantoin
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ISSN0040-4039
DOI10.1016/j.tetlet.2011.10.118

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Summary:An efficient method for the liquid-phase synthesis of 3,5-disubstituted thiohydantoins has been developed. This new class of substituted thiohydantoins was tested as DNA fluorescence probes. Anthracene-substituted thiohydantoin undergoes a change in fluorescence in the presence of DNA. (C) 2011 Elsevier Ltd. All rights reserved.
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ISSN:0040-4039
DOI:10.1016/j.tetlet.2011.10.118