Is Salivary Α-Amylase a Reliable Indicator of Psychological Status and Quality of Life in Patients with Oral Lichen Planus: a Case-Control Study

• Published in: Cellular physiology and biochemistry Vol. 58; no. 3; pp. 311 - 321
• Main Authors: Glavina, Ana, Zoranić, Antonija, Tadin, Antonija, Cigić, Livia, Šupe-Domić, Daniela, Lugović-Mihić, Liborija
• Format: Journal Article
• Language: English
• Published: Germany Cell Physiol Biochem Press GmbH & Co KG 12.07.2024
• Subjects: Adult; Aged; Anxiety; Biomarkers - metabolism; Case-Control Studies; Depression; Female; Humans; Lichen Planus, Oral - metabolism; Lichen Planus, Oral - psychology; Male; Middle Aged; Quality of Life; Saliva - chemistry; Saliva - enzymology; Saliva - metabolism; Salivary alpha-Amylases - analysis; Salivary alpha-Amylases - metabolism; Surveys and Questionnaires; Alpha-amylase ; Biomarkers ; Oral lichen planus ; Quality of life ; Saliva
• ISSN: 1015-8987; 1421-9778; 1421-9778
• DOI: 10.33594/000000714

Background/Aims: The objectives of our study were to determine salivary α-amylase activity (stress biomarker) and its association with psychological status and quality of life (QoL), disease duration and intensity of symptoms (pain/burning) in patients with OLP. Methods: A total of 50 subjects participated in this case-control study: 30 patients with oral lichen planus (OLP); 20 control subjects. Unstimulated whole saliva (UWS) was collected between 9 and 10 am to avoid diurnal fluctuations. Psychological status was assessed using the Croatian validated version of the original Depression, Anxiety and Stress Scale (DASS-21). The impact of oral health on QoL was assessed using the Croatian version of the Oral Health Impact Profile Questionnaire (OHIP-CRO14). Results: There was no statistically significant difference in salivary α-amylase activity between patients with OLP (N=30) and control subjects (N=20) (133813.3 vs. 166815.5 U/L, p=0.314; t-test). Depression, anxiety and stress showed no statistically significant difference between patients with OLP and control subjects (p=0.076, p=0.111, p=0.209; t-test). The patients with OLP had statistically significantly poorer QoL (total) compared to control subjects (p=0.004, t-test). There was a moderate positive correlation between symptom intensity (pain/burning) and poor QoL (total) (r=0.584, p<0.001), the OHIP-CRO14 dimension “physical pain” (r=0.661, p<0.001), “psychological impossibility” (r=0.555, p<0.01), “handicap” (r=0.546, p<0.01). Conclusion: Although salivary α-amylase showed no statistically significant difference between patients with OLP and control subjects, the patients with OLP had poorer psychological status (three times higher scores for depression and two times higher scores for anxiety) and poorer QoL compared to the control subjects. Recognising and treating mental disorders in patients with OLP is important in order to break the „vicious circle“ and achieve a better QoL in these patients.