Shark Cartilage Extracts as Antiangiogenic Agents: Smart Drinks or Bitter Pills?

The use of crude cartilage for the treatment of human cancers remains a subject of controversy. In this brief commentary, we reviewed the current knowledge on the anticancer properties of cartilage. We then presented the properties of AE-941, a novel standardized water-soluble extract derived from s...

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Published inCancer and metastasis reviews Vol. 19; no. 1-2; pp. 83 - 86
Main Authors Gingras, Denis, Renaud, Alain, Mousseau, Nathalie, Béliveau, Richard
Format Journal Article
LanguageEnglish
Published Netherlands Springer Nature B.V 2000
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ISSN0167-7659
1573-7233
DOI10.1023/A:1026504500555

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Summary:The use of crude cartilage for the treatment of human cancers remains a subject of controversy. In this brief commentary, we reviewed the current knowledge on the anticancer properties of cartilage. We then presented the properties of AE-941, a novel standardized water-soluble extract derived from shark cartilage that represents less than 5% of the crude cartilage. It is a multifunctional antiangiogenic product that contains several biologically active molecules. EA-941 is one of the few antiangiogenic drugs that is under phase III clinical investigation. It is currently evaluated in Europe and North America for the treatment of refractory renal cell carcinoma and in North America for metastatic non small cell lung cancer.
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ISSN:0167-7659
1573-7233
DOI:10.1023/A:1026504500555