Anti-tumor Action and Clinical Application of Proteasome Inhibitor

Ubiquitin-proteasome pathway mediates the degradation of cell protein, and cell cycle, gene translation and expression, antigen presentation and inflammatory development. Proteasome inhibitor can inhibit growth and proliferation of tumor cell, induce apoptosis and reverse multipledrug resistance of...

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Bibliographic Details
Published inChinese journal of cancer research Vol. 20; no. 2; pp. 77 - 84
Main Author 周咏明 余美霞 龙辉 黄士昂
Format Journal Article
LanguageEnglish
Published Heidelberg Chinese Anti-Cancer Association 01.06.2008
Department of hematology,The Affiliated Hospital,Wuhan University of Science and Technology,Wuhan 430000%Stem Cell Center,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022
Subjects
Medicine
Medicine & Public Health
Review
临床研究
抑制剂
抗癌性能
Tumor
R963
Ubiquitin-proteasome pathway
Proteasome inhibitor
Online AccessGet full text
ISSN1000-9604
1993-0631
DOI10.1007/s11670-008-0077-1

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Summary:Ubiquitin-proteasome pathway mediates the degradation of cell protein, and cell cycle, gene translation and expression, antigen presentation and inflammatory development. Proteasome inhibitor can inhibit growth and proliferation of tumor cell, induce apoptosis and reverse multipledrug resistance of tumor cell, increase the sensitivity of other chemotherapeutic drugs and radiotherapy, and is a novel class of potent anti-tumor agents.
Bibliography:Proteasome inhibitor; Ubiquitin-proteasome pathway; Tumor
11-2591/R
Tumor
R963
Ubiquitin-proteasome pathway
Proteasome inhibitor
ISSN:1000-9604
1993-0631
DOI:10.1007/s11670-008-0077-1