Construction of an aggregation-induced electrochemiluminescent sensor based on an aminal-linked covalent organic framework for sensitive detection of glutathione in human serum

• Published in: Chemical communications (Cambridge, England) Vol. 58; no. 75; pp. 1524 - 1527
• Main Authors: Song, Linlin, Gao, Wenqiang, Han, Qinru, Huang, Yiping, Cui, Lin, Zhang, Chun-yang
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 20.09.2022
• Subjects: Agglomeration; blood serum; Electrochemiluminescence; Energy transfer; Glutathione; humans; Manganese dioxide; nanosheets; Nanostructure; Selectivity
• ISSN: 1359-7345; 1364-548X; 1364-548X
• DOI: 10.1039/d2cc03753j

We demonstrate the construction of an aggregation-induced electrochemiluminescent (AIECL) sensor for glutathione (GSH) assay by integrating an aminal-linked covalent organic framework (A-COF) with manganese dioxide (MnO 2 ) nanosheets. The AIECL of the A-COF is quenched by the MnO 2 nanosheets via electrochemiluminescent resonance energy transfer (ERET) from the excited A-COF to MnO 2 . The presence of GSH can reduce the MnO 2 nanosheets into Mn 2+ , restoring the AIECL emission of the A-COF. This AIECL sensor has the characteristics of fast response, high sensitivity, and good selectivity toward GSH, and it can accurately measure GSH in human serum. We develop an aggregation-induced electrochemiluminescent sensor to sensitively detect glutathione in human serum.