Anaplastic Large Cell Lymphoma Involving Anterior Segment of the Eye

• Published in: Korean journal of ophthalmology Vol. 28; no. 1; pp. 108 - 112
• Main Authors: Park, Choul Yong, Hwang, Sang Won, Kim, Do Yeun, Huh, Hee Jin, Oh, Jong-Hyun
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Ophthalmological Society 01.02.2014; 대한안과학회
• Subjects: Adult; Anterior Eye Segment - pathology; Biopsy; Case Report; Diagnosis, Differential; Eye Neoplasms - diagnosis; Female; Humans; Lymphoma, Large-Cell, Anaplastic - diagnosis; Magnetic Resonance Imaging; Neoplasm Invasiveness; Positron-Emission Tomography; 안과학; Eye; Acute angle closure; Radiotherapy; Anaplastic large cell lymphoma
• ISSN: 1011-8942; 2092-9382; 2092-9382
• DOI: 10.3341/kjo.2014.28.1.108

A 36-year-old woman was diagnosed with anaplastic large cell lymphoma (ALCL) by excisional biopsy of a left frontal skin lesion. During the first cycle of chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisolone), the patient complained of right ocular pain and inflammation. Cytologic examination using aqueous humor revealed atypical lymphocytes, suggesting intraocular ALCL involvement. Acute angle closure developed in the anterior chamber due to rapid progression of ALCL, causing pupillary block. Laser and surgical interventions were attempted but failed to relieve the pupillary block. Finally, radiation therapy resolved the pupillary block to restore the anterior chamber and normalize intraocular pressure. This is the first case in the English literature of ALCL involving the iris to cause acute secondary angle closure.