Factors Affecting Treatment Outcome of Graft Infection Following Penetrating Keratoplasty

• Published in: Korean journal of ophthalmology Vol. 29; no. 5; pp. 301 - 308
• Main Authors: Sung, Mi Sun, Choi, Won, You, In Cheon, Yoon, Kyung Chul
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Ophthalmological Society 01.10.2015; 대한안과학회
• Subjects: Adult; Aged; Aged, 80 and over; Eye Infections, Bacterial - diagnosis; Eye Infections, Bacterial - etiology; Eye Infections, Fungal - diagnosis; Eye Infections, Fungal - etiology; Female; Graft Survival; Humans; Keratoplasty, Penetrating - adverse effects; Male; Middle Aged; Original; Prognosis; Retrospective Studies; Risk Factors; Surgical Wound Infection - diagnosis; Surgical Wound Infection - etiology; Treatment Outcome; 안과학; Prognostic factor; Treatment outcome; Penetrating keratoplasty; Graft infection
• ISSN: 1011-8942; 2092-9382
• DOI: 10.3341/kjo.2015.29.5.301

To evaluate the factors affecting treatment outcome of graft infection following penetrating keratoplasty (PKP). In this retrospective study, 28 patients who underwent PKP between January 2005 and January 2013 and who were diagnosed with graft infection were classified into a treatment success group or a treatment failure group. Demographic and clinical characteristics, as well as the results of the microbiologic investigation, were analyzed and compared. A subsequent binary logistic regression analysis was performed to identify the prognostic factors affecting treatment outcome. Graft infection occurred at a mean of 38.29 ± 36.16 months (range, 1 to 96 months) after PKP. Seventeen patients developed bacterial keratitis, and 11 patients developed fungal keratitis. Overall, of the 28 patients, nine (32.1%) were classified in the treatment failure group. Multivariate analysis identified pre-existing graft failure (p = 0.019), interval longer than 72 hours between donor death and PKP (p = 0.010), and fungal infection (p = 0.026) as significant risk factors for treatment failure. Pre-existing graft failure, extended interval between donor death and PKP, and fungal infection were important risk factors for treatment failure of graft infection following PKP.