Second messenger control of chromatin remodeling

Two recent studies show that some ATP-dependent chromatin remodeling complexes are subject to control by a surprising set of regulators — phosphoinositols. These studies extend earlier observations in mammalian cells and suggest that second messengers are regulators of chromatin remodeling.

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Bibliographic Details
Published in	Nature Structural Biology Vol. 10; no. 2; pp. 81 - 83
Main Authors	Rando, Oliver J., Chi, Tian H., Crabtree, Gerald R.
Format	Journal Article
Language	English
Published	New York Nature Publishing Group US 01.02.2003 Nature Publishing Group
Subjects	Adenosine Triphosphate - metabolism Animals Biochemistry Biological Microscopy Biomedical and Life Sciences Chromatin - chemistry Chromatin - genetics Chromatin - metabolism Inositol Phosphates - metabolism Life Sciences Membrane Biology news-and-views Protein Structure Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Second Messenger Systems T-Lymphocytes - metabolism
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ISSN	1072-8368 1545-9993 1545-9985
DOI	10.1038/nsb0203-81

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Summary:	Two recent studies show that some ATP-dependent chromatin remodeling complexes are subject to control by a surprising set of regulators — phosphoinositols. These studies extend earlier observations in mammalian cells and suggest that second messengers are regulators of chromatin remodeling.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 14 content type line 23 ObjectType-News-1
ISSN:	1072-8368 1545-9993 1545-9985
DOI:	10.1038/nsb0203-81