Synthesis of functionalized SBA-15 with ordered large pore size and its adsorption properties of BSA

• Published in: Microporous and mesoporous materials Vol. 110; no. 2; pp. 560 - 569
• Main Authors: Nguyen, Thi Phuong Binh, Lee, Jae-Wook, Shim, Wang Geun, Moon, Hee
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 15.04.2008; Elsevier
• Subjects: Adsorption; Bovine serum albumin; Chemistry; Colloidal state and disperse state; Exact sciences and technology; Functionalized SBA-15; General and physical chemistry; Porous materials; Release; Surface physical chemistry; Bovine serum albumin; Adsorption; Functionalized SBA-15; Release; Bovine; Albumin; Serum albumin; Porous material; Mesoporosity; Vertebrata; Pore size; Mammalia; Synthesis; Pore; Artiodactyla; Ungulata
• ISSN: 1387-1811; 1873-3093
• DOI: 10.1016/j.micromeso.2007.06.054

SBA-15, mesoporous material, is a very excellent candidate for drug delivery system because its pore size is easy to control according to synthesis conditions and the presence of swelling agent. In this study, a known swelling agent, 1,3,5-trimethylbenzene (TMB), was used to increase the pore size with increased aging temperature and prolonged aging time. Furthermore, 3-aminopropyltriethoxysilane (APTES) was incorporated on SBA-15 surface via post synthesis method to separate protein effectively. The samples were characterized by X-ray diffraction (XRD), nitrogen adsorption and desorption analyses, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Fourier Transform Infrared (FT-IR). Adsorption capacity increased with temperature at the isoelectric point (pI) of bovine serum albumin (BSA) regardless of the pore size of SBA-15 samples. Release studies were carried out in the range of pH from neutral to basic solution on unmodified and amine-modified samples. In addition, the adsorption mechanism was investigated by employing the pseudo-first order, pseudo-second order, and intraparticle diffusion models.