The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women

• Published in: Endocrine Vol. 43; no. 1; pp. 127 - 135
• Main Authors: Deng, Yan-Hua, Zhao, Lin, Zhang, Min-Jia, Pan, Chun-Ming, Zhao, Shuang-Xia, Zhao, Hong-Yan, Sun, Li-Hao, Tao, Bei, Song, Huai-Dong, Wang, Wei-Qing, Ning, Guang, Liu, Jian-Min
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.02.2013
• Subjects: Accidental Falls; Adult; Aged; Aging; Asian Continental Ancestry Group; Bone Density; China; Cohort Studies; Cross-Sectional Studies; Diabetes; Endocrinology; Female; Genetic Association Studies; Hip Joint - diagnostic imaging; Hip Joint - metabolism; Humanities and Social Sciences; Humans; Internal Medicine; Lumbar Vertebrae - diagnostic imaging; Lumbar Vertebrae - metabolism; MADS Domain Proteins - genetics; MADS Domain Proteins - metabolism; Medicine; Medicine & Public Health; MEF2 Transcription Factors; Middle Aged; multidisciplinary; Myogenic Regulatory Factors - genetics; Myogenic Regulatory Factors - metabolism; Original Article; Osteoporosis, Postmenopausal - ethnology; Osteoporosis, Postmenopausal - genetics; Osteoporosis, Postmenopausal - metabolism; Osteoporosis, Postmenopausal - physiopathology; Osteoporotic Fractures - ethnology; Osteoporotic Fractures - etiology; Osteoporotic Fractures - genetics; Osteoporotic Fractures - metabolism; Osteoprotegerin - genetics; Osteoprotegerin - metabolism; Polymorphism, Single Nucleotide; Radiography; Science; Spectrin - genetics; Spectrin - metabolism; Young Adult; BMD; Osteoporosis; Non-genetic factors; Genetic factors; Osteoporotic fractures
• ISSN: 1355-008X; 1559-0100; 1559-0100
• DOI: 10.1007/s12020-012-9726-8

To investigate the effects of genetic and non-genetic factors on bone mineral densities (BMDs) and osteoporotic fractures. This was a cross-sectional study to investigate the relationships between 18 SNPs and non-genetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women. Five SNPs in genes GPR177, CTNNB1, MEF2C, SOX6, and TNFRSF11B were associated with L1-4 or total hip BMDs. rs11898505 in SPTBN1 gene was associated with osteoporotic fractures. Subjects carrying the largest number of risk alleles (highest 10 %) not only had lower BMD values as compared to those carrying the least number of risk alleles (lowest 10 %), they also had a higher risk of fracture [ P  = 0.002, OR = 2.252, 95 %CI (1.136, 4.463)]. Results from multivariate stepwise regression analysis revealed that age [ P  < 0.001, OR = 1.038, 95 % CI (1.018, 1.058)], number of falls in a year [ P  < 0.001, OR = 2.347, 95 % CI (1.459, 3.774)], the G risk allele in rs11898505 [ P  = 0.023, OR = 1.559, 95 % CI (1.062, 2.290)], and the L1-4 BMD [ P  = 0.017, OR = 0.286, 95 % CI (0.102, 0.798)] were associated with the occurrence of osteoporotic fractures. Genetic (rs11898505) and non-genetic factors (age, number of falls in a year and L1-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures.