En route to local glioblastoma treatment with temozolomide doped hyaluronan fibres: formulation and in vitro cell studies

We report the preparation, characterisation and in vitro tests of hyaluronan fibres containing up to 50 w/w% of temozolomide for local glyoblastoma treatment. These fibres form a hydrogel upon contact with cerebrospinal fluid on the treatment spot.

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Bibliographic Details
Published inRSC medicinal chemistry Vol. 14; no. 9; pp. 1662 - 1666
Main Authors Belhajová, Marie, Vícha, Aleš, Burgert, Ladislav, Brožková, Iveta, Michalíčková, Ludmila, Hrdina, Radim, Moravec, Tomáš, Netuka, David, Musil, Zdeněk
Format Journal Article
LanguageEnglish
Published RSC 19.09.2023
Subjects
Chemistry
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ISSN2632-8682
2632-8682
DOI10.1039/D3MD00261F

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Summary:We report the preparation, characterisation and in vitro tests of hyaluronan fibres containing up to 50 w/w% of temozolomide for local glyoblastoma treatment. These fibres form a hydrogel upon contact with cerebrospinal fluid on the treatment spot.
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ISSN:2632-8682
2632-8682
DOI:10.1039/D3MD00261F