POSS-modified PEG Adhesives for Wound Closure

• Published in: Chinese journal of polymer science Vol. 35; no. 10; pp. 1231 - 1242
• Main Authors: Bu, Ya-zhong, Sun, Guo-fei, Zhang, Li-cheng, Liu, Jian-heng, Yang, Fei, Tang, Pei-fu, Wu, De-cheng
• Format: Journal Article
• Language: English
• Published: Beijing Chinese Chemical Society and Institute of Chemistry, CAS 01.10.2017; Springer Nature B.V
• Subjects: Adhesive strength; Adhesives; Biocompatibility; Cell adhesion; Cell adhesion & migration; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Condensed Matter Physics; Healing; In vitro methods and tests; Industrial Chemistry/Chemical Engineering; Inflammatory response; Polymer Sciences; POSS; Toxicity; 伤口; 体外细胞毒性; 改性; 生物相容性; 粘合剂; 细胞生长; 聚乙二醇; POSS; Adhesives; PEG; Hydrogel; Wound closure
• ISSN: 0256-7679; 1439-6203
• DOI: 10.1007/s10118-017-1958-x

PEG-related adhesives are limited in clinical use because they are easy to swell and cannot support the cell growth. In this study, we produced a series of POSS-modified PEG adhesives with high adhesive strength. Introduction of inorganic hydrophobic POSS units decreased the swelling of the adhesives and enhanced cell adhesion and growth. The in vitro cytotoxicity and in vivo inflammatory response experiments clearly demonstrated that the adhesives were nontoxic and possessed excellent biocompatibility. Compared with the sutured wounds, the adhesive-treated wounds showed an accelerated healing process in wounded skin model of the Bama miniature pig, demonstrating that the POSS-modified PEG adhesive is a promising candidate for wound closure.