Amlodipine Reduces Predicted Risk of Coronary Heart Disease in High-Risk Patients with Hypertension in Spain (The CORONARIA Study)

• Published in: Journal of international medical research Vol. 36; no. 6; pp. 1399 - 1417
• Main Authors: Zamorano, J, Padial, L Rodriguez, Cosín, J, Hernandiz, A, Gutierrez-Chico, JL, de Isla, L Pérez, Arístegui, R, Masramon, X
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.11.2008
• Subjects: Amlodipine - therapeutic use; Antihypertensive Agents - therapeutic use; Blood Pressure - drug effects; Cohort Studies; Coronary Disease - complications; Coronary Disease - drug therapy; Coronary Disease - physiopathology; Drug Therapy, Combination; Female; Humans; Hypertension - complications; Hypertension - drug therapy; Hypertension - physiopathology; Male; Middle Aged; Primary Health Care; Prospective Studies; Risk Factors; Treatment Outcome; Hypertension; Amlodipine besylate; Antihypertensive agent; Blood pressure; Cardiovascular risk
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/147323000803600630

We evaluated the efficacy and safety of amlodipine besylate alone or in combination with other antihypertensive agents in high-risk hypertensive patients in Spanish primary care. In this 1-year, open-label, prospective cohort study, 7468 patients were treated with amlodipine 5–10 mg as a monotherapy or as an add-on therapy to attain blood pressure control (target of < 140/90 mmHg or, in patients with conditions such as diabetes or chronic kidney disease, < 130/85 mmHg). At 12 months, the primary outcome (change from baseline in predicted 10-year coronary heart disease risk) was −8.6%, down from 24.7% at baseline (relative risk reduction, 31.6%). Change in blood pressure from baseline (162.5/95.3 mmHg) was −26.7/-14.6 mmHg, and 38.6% of patients achieved their blood pressure target. In summary, significant reductions in predicted coronary heart disease risk and blood pressure were observed with amlodipine both as a monotherapy and as an add-on therapy. Amlodipine was well tolerated and compliance with treatment was good.