Biofunctionalized carbon nanotubes in neural regeneration: a mini-review
Carbon nanotubes (CNTs) have become an intriguing and promising biomaterial platform for the regeneration and functional recovery of damaged nerve tissues. The unique electrical, structural and mechanical properties, diversity of available surface chemistry and cell-penetrating ability of CNTs have...
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| Published in | Nanoscale Vol. 5; no. 2; pp. 487 - 497 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
21.01.2013
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2040-3364 2040-3372 2040-3372 |
| DOI | 10.1039/c2nr31581e |
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| Summary: | Carbon nanotubes (CNTs) have become an intriguing and promising biomaterial platform for the regeneration and functional recovery of damaged nerve tissues. The unique electrical, structural and mechanical properties, diversity of available surface chemistry and cell-penetrating ability of CNTs have made them useful implantable matrices or carriers for the delivery of therapeutic molecules. Although there are still challenges being faced in the clinical applications of CNTs mainly due to their toxicity, many studies to overcome this issue have been published. Modification of CNTs with chemical groups to ensure their dissolution in aqueous media is one possible solution. Functionalization of CNTs with biologically relevant and effective molecules (biofunctionalization) is also a promising strategy to provide better biocompatibility and selectivity for neural regeneration. Here, we review recent advances in the use of CNTs to promote neural regeneration.
Biofunctionalization of CNTs with therapeutic molecules for neural regeneration as cell penetrating vehicles and 3D cell regulating substrates. |
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| Bibliography: | Dr Ueon Sang Shin graduated from the Technical University of Aachen (RWTH Aachen), Germany, in 1999 with a degree in chemistry and subsequently obtained his PhD in 2002. He worked as a research professor from 2006 to 2008 at Sungkyunkwan University, South Korea. He joined the Institute of Tissue Regeneration Engineering at Dankook University, South Korea, in 2009. In 2011 he took up the position of assistant professor in the Department of Nanobiomedical Science and WCU Research Center at Dankook University, South Korea. His areas of expertise include organic nano-materials and their applications to tissue regeneration. Dr Won-Cheoul Jang obtained his PhD degree in Biochemistry from the University of Southern Mississippi, USA, in 1990. From 1993 to 1995 he worked at the Korean Research Institute of Chemical Safety Research Center. In March 1995, he became a professor at the Department of Chemistry, Dankook University, South Korea. His research interests include: drug delivery systems for therapeutic biofactors, clinical research and industries, elucidation of the disease-associated mechanisms of genetic polymorphisms, and development of biosensors using nanomaterials. Dr Ivan Wall obtained his PhD degree in Cell and Molecular Biology in 2006 from Cardiff University, UK. From 2006 to 2009, he worked as a post-doctoral researcher at University College London, UK. Since 2009 he has been a lecturer in the Department of Biochemical Engineering, UCL and joined the WCU at Dankook University, South Korea in 2010. His research group at UCL work on addressing the scientific and commercial challenges of creating cell therapies. At Dankook University, he contributes his expertise in basic and applied stem cell technology to facilitate vascular and musculoskeletal tissue engineering, mechanical cues to regulate stem cell differentiation, and modulation of 3D substrates for large-scale production. Dr Ji-Young Hwang received her PhD degree in Biochemistry from the University of Duesseldorf, Germany, in 2001. She worked as a research scientist at the National Institutes of Health, Maryland, USA from 2003 to 2006 and as a government officer at the National Institute of Health, South Korea, from 2006 to 2008. In 2009 she moved to the Samsung Biomedical Research Institute as a senior scientist and joined Institute of Tissue Regeneration Engineering at Dankook University, South Korea, as a research professor in 2011. Her main research activities focus on elucidation of molecular mechanisms and cellular processes in human nerve diseases and exploration of regeneration-targeted genes/proteins. Dr Hae-Won Kim studied Materials Science and Engineering at Seoul National University, South Korea, from 1993-1997, then completed his PhD degree in 2002. He spent time at the National Institute of Standards and Technology (NIST), USA, during 2000, studying biomechanics of dental biomaterials. He continued to work in the area of biomaterials and tissue engineering at the Eastman Dental Institute, University College London, UK with the International Fellowship from the Royal Society from 2003-2004. He is now a professor of Dankook University Dental School as well as an adjunct professor of the interdisciplinary Department of Nanobiomedical Science. He leads the team of Institute of Tissue Regeneration Engineering, designated as the National Strategic Research Center from 2009. His research interests include development of regenerative biomaterials and 3D culture methodologies for stem cells and their differentiation into musculoskeletal, dental and neural tissues. Currently he is the editor-in-chief of the international journal 'Journal of Tissue Engineering'. Dr. Jung Keun Hyun obtained his MD degree at Dankook University, South Korea in 1994, and has been a specialist in rehabilitation medicine since 1999. After completing his PhD degree in 2002, he obtained a position as an assistant professor at the Department of Rehabilitation Medicine, Dankook University College of Medicine, South Korea. In 2005, he was awarded the Young Scientist Award at the 3rd world congress of International Society of Physical and Rehabilitation Medicine (ISPRM). Now he is an associate professor of the Department of Nanobiomedical Science and WCU Research Center at Dankook University, South Korea. His clinical fields and research areas include spinal cord rehabilitation, spinal cord and peripheral nerve regeneration using stem cells and biomaterial scaffolds, and electrodiagnostic medicine. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| ISSN: | 2040-3364 2040-3372 2040-3372 |
| DOI: | 10.1039/c2nr31581e |