Erythropoietin improves spatial learning and memory in streptozotocin model of dementia

• Published in: Pathophysiology (Amsterdam) Vol. 20; no. 2; pp. 153 - 158
• Main Authors: Hamidi, Gholamali, Arabpour, Zohreh, Shabrang, Moloud, Rashidi, Bahman, Alaei, Hojjatallah, Sharifi, Mohammad Reza, Salami, Mahmoud, Reisi, Parham
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 01.04.2013
• Subjects: Alzheimer disease; Dementia; Erythropoietin; Intracerebroventricular injections; Learning and Memory; Male rats; Streptozotocin; Erythropoietin; Intracerebroventricular injections; Alzheimer disease; Male rats; Streptozotocin; Learning and Memory; Dementia
• ISSN: 0928-4680; 1873-149X
• DOI: 10.1016/j.pathophys.2013.01.001

Alzheimer's disease is associated to impairments of learning and memory. Because studies demonstrated that erythropoietin has positive effects on central nervous system, the aim of this study was to evaluate the effect of erythropoietin on spatial learning and memory in a well defined model for Alzheimer's disease. Rat model of Alzheimer's was created by injecting streptozotocin in lateral ventricles of the brain. Two weeks later, the rats were assessed through passive avoidance learning test to confirm the induction of Alzheimer's. After that, they received erythropoietin (5000IU/kg) every other day, for two weeks and then spatial learning and memory were assessed by a 5-day protocol of Morris water maze test in them. The results showed that streptozotocin severely damaged learning and memory in rats. Erythropoietin had no significant effect in the control rats; however, it significantly improved learning and memory in rats with Alzheimer's disease, as the task performance of the rats treated with erythropoietin was like the control group. The results suggest that erythropoietin can be considered as an effective treatment for neurodegenerative damages.