In vitro 3D skin model using gelatin methacrylate hydrogel

[Display omitted] Interests in in vitro skin models have been growing. Collagen, which is a main scaffold material for in vitro 3D skin models, has weak mechanical properties, often resulting in undesirable contraction. The physiological characteristics of the skin models often depend on the matrix...

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Published inJournal of industrial and engineering chemistry (Seoul, Korea) Vol. 66; pp. 254 - 261
Main Authors Kwak, Bong Shin, Choi, Wonho, Jeon, Joong-won, Won, Jong-In, Sung, Gun Yong, Kim, Bumsang, Sung, Jong Hwan
Format Journal Article
LanguageEnglish
Published Elsevier B.V 25.10.2018
한국공업화학회
Subjects
Extracellular matrix
Fibroblasts
Gelatin methacrylate
In vitro skin models
Keratinocytes
화학공학
Fibroblasts
Keratinocytes
In vitro skin models
Extracellular matrix
Gelatin methacrylate
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ISSN1226-086X
1876-794X
DOI10.1016/j.jiec.2018.05.037

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Summary:[Display omitted] Interests in in vitro skin models have been growing. Collagen, which is a main scaffold material for in vitro 3D skin models, has weak mechanical properties, often resulting in undesirable contraction. The physiological characteristics of the skin models often depend on the matrix in which cells are cultured. In this study, we developed a 3D skin model using gelatin methacrylate. The mechanical and transport properties were studied, and attachment and growth of fibroblasts and keratinocytes were examined. Fibroblasts preferred softer matrix, whereas HaCaT cells preferred harder matrix of gelatin methacrylate. This study provides information for developing in vitro skin models.
ISSN:1226-086X
1876-794X
DOI:10.1016/j.jiec.2018.05.037