FLASH-Radiotherapy: A Potential Innovation Driver in Radiation Therapy

In recent times, radiation therapy (RT) involving ultra-high dose rates of ionizing radiation, known as FLASH-RT, has been of great interest. Through this technology, the radiation dose can be delivered almost instantaneously within milliseconds. Many in vitro and in vivo studies have demonstrated t...

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Bibliographic Details
Published inJournal of the Korean Physical Society Vol. 77; no. 5; pp. 357 - 362
Main Authors Seo, Young-Seok, Park, Woo-Yoon, Min, Byung Jun, Choi, Kyungdon, Kim, Ki-Whwan
Format Journal Article
LanguageEnglish
Published Seoul The Korean Physical Society 01.09.2020
Springer Nature B.V
한국물리학회
Subjects
Biocompatibility
In vivo methods and tests
Ionizing radiation
Mathematical and Computational Physics
Particle and Nuclear Physics
Physics
Physics and Astronomy
Radiation dosage
Radiation effects
Radiation therapy
Theoretical
Toxicity
물리학
Radiation Therapy
FLASH
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ISSN0374-4884
1976-8524
DOI10.3938/jkps.77.357

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Summary:In recent times, radiation therapy (RT) involving ultra-high dose rates of ionizing radiation, known as FLASH-RT, has been of great interest. Through this technology, the radiation dose can be delivered almost instantaneously within milliseconds. Many in vitro and in vivo studies have demonstrated that FLASH-RT can significantly improve normal tissue tolerance from radiation induced toxicity; this improvement is called the FLASH effect. Very recently, encouraging results from FLASH-RT on human patients have been reported, which has extended the applicability of FLASH-RT to clinical practice. In this review, we will discuss the results of the current research on FLASH-RT and consider the challenges to be overcome prior to the clinical application of FLASH-RT.
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ISSN:0374-4884
1976-8524
DOI:10.3938/jkps.77.357