Expression of IL-33 and TSLP and Their Receptors in Asthmatic Airways after Inhaled Allergen Challenge

• Published in: American journal of respiratory and critical care medicine Vol. 198; no. 6; pp. 805 - 807
• Main Authors: Al-Sajee, Dhuha, Sehmi, Roma, Hawke, Thomas J., El-Gammal, Amani, Howie, Karen J., Watson, Richard M., Londei, Marco, Gauvreau, Gail M., O’Byrne, Paul M.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 15.09.2018
• Subjects: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Allergens - immunology; Allergens - pharmacology; Allergies; Asthma; Asthma - immunology; Asthma - metabolism; Biopsy; Cytokines; Cytokines - metabolism; Dendritic cells; Female; Humans; Interleukin-1 Receptor-Like 1 Protein - metabolism; Interleukin-33 - metabolism; Male; Middle Aged; Receptors, Cytokine - metabolism; Respiratory System - immunology; Respiratory System - metabolism; Young Adult; Canada; United States > US; California
• ISSN: 1073-449X; 1535-4970; 1535-4970
• DOI: 10.1164/rccm.201712-2468LE

The biological effects of IL-33 are mediated through IL-1 receptor family member ST2, which is expressed on effector cells such as eosinophils, mast cells, T-helper cell type 2 (Th2) cells, and group 2 innate lymphoid cells (2, 5). [...]targeting the airway epithelium with therapeutics specific to these cytokines may be advantageous for modulating asthmatic responses to allergens. ? Expression profile of interleukin-33 (IL-33), interleukin-1 receptor family member (IL1RL1, ST2) and thymic stromal lymphopoietin (TSLP) in airway epithelium from asthmatic subjects after allergen challenge.