In Vitro Effect of Cyclosporine on Interleukin-2 Receptor Expression Stimulated by Cryptococcus neoformans

• Published in: The Journal of infectious diseases Vol. 155; no. 4; pp. 799 - 802
• Main Authors: Miller, G. P. G., Lewis, Dorothy E.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.04.1987; University of Chicago Press
• Subjects: Antigens; Biological and medical sciences; Cell lines; Cells, Cultured; Concise Laboratory and Clinical Communications; Cryptococcosis - immunology; Cryptococcus - immunology; Cryptococcus neoformans; Cryptococcus neoformans - immunology; Cultured cells; cyclosporin A; Cyclosporins; Cyclosporins - pharmacology; Cytometry; Humans; Immunomodulators; Infectious diseases; interleukin-2; Interleukin-2 - biosynthesis; Lymphocyte Activation; Lymphocytes; Medical sciences; Messenger RNA; Pharmacology. Drug treatments; Receptors; Receptors, Immunologic - drug effects; Receptors, Interleukin-2; T lymphocytes; Lymphokine; Immunosuppressive agent; Interleukin 2; In vitro; Biological receptor
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/155.4.799

In the experiments reported here, the authors found that CsA inhibited proliferative responses of nonimmune controls at doses as low as 5 ng/ml, a level well below the concentration required to inhibit responses to antigens of the major histocompatibility complex. The concentration required to inhibit secondary responses of immune subjects and to inhibit production of IL-2 was higher (30 ng/ml) but still below the typical serum trough concentrations used clinically. In addition to inhibiting IL-2 production, CsA depressed IL-2 receptor expression during in vitro primary responses.