APOBEC3 deletion increases the risk of breast cancer: a meta-analysis
Recently, a deletion in the human apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) gene cluster has been associated with a modest increased risk of breast cancer, but studies yielded inconsistent results. Therefore we performed a meta-analysis to derive a more precise conc...
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| Published in | Oncotarget Vol. 7; no. 46; pp. 74979 - 74986 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Impact Journals LLC
15.11.2016
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| Online Access | Get full text |
| ISSN | 1949-2553 1949-2553 |
| DOI | 10.18632/oncotarget.11792 |
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| Abstract | Recently, a deletion in the human apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) gene cluster has been associated with a modest increased risk of breast cancer, but studies yielded inconsistent results. Therefore we performed a meta-analysis to derive a more precise conclusion. Six studies including 18241 subjects were identified by searching PubMed and Embase databases from inception to April 2016. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were evaluated under allele contrast, dominant, recessive, homozygous, and heterozygous models. All the analyses suggested a correlation of APOBEC3 deletion with increased breast cancer risk (D vs I: OR = 1.29, 95% CI = 1.23-1.36; D/D+I/D vs I/I: OR = 1.34, 95% CI = 1.26-1.43; D/D vs I/D+ I/I: OR = 1.51, 95% CI = 1.36-1.68; D/D vs I/I: OR = 1.75, 95% CI= 1.56-1.95; I/D vs I/I: OR = 1.28, 95% CI = 1.19-1.36). Stratified analysis by ethnicity showed that the relationship is stronger and more stable in Asians. In summary, our current work indicated that APOBEC3 copy number variations might have a good screening accuracy for breast cancer. |
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| AbstractList | Recently, a deletion in the human apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) gene cluster has been associated with a modest increased risk of breast cancer, but studies yielded inconsistent results. Therefore we performed a meta-analysis to derive a more precise conclusion. Six studies including 18241 subjects were identified by searching PubMed and Embase databases from inception to April 2016. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were evaluated under allele contrast, dominant, recessive, homozygous, and heterozygous models. All the analyses suggested a correlation of APOBEC3 deletion with increased breast cancer risk (D vs I: OR = 1.29, 95% CI = 1.23-1.36; D/D+I/D vs I/I: OR = 1.34, 95% CI = 1.26-1.43; D/D vs I/D+ I/I: OR = 1.51, 95% CI = 1.36-1.68; D/D vs I/I: OR = 1.75, 95% CI= 1.56-1.95; I/D vs I/I: OR = 1.28, 95% CI = 1.19-1.36). Stratified analysis by ethnicity showed that the relationship is stronger and more stable in Asians. In summary, our current work indicated that APOBEC3 copy number variations might have a good screening accuracy for breast cancer. |
| Author | He, Qin Sun, Yuping Zhou, Guanzhou Wang, Shuyun Han, Yali Qi, Qichao Sun, Meili |
| AuthorAffiliation | 3 Department of Endocrine and Metabolism, Qilu Hospital of Shandong University, Jinan, 250012, China 4 Department of General Surgery, Qilu Hospital of Shandong University, Jinan, 250012, China 1 Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, 250013, China 2 Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Jinan, 250012, China |
| AuthorAffiliation_xml | – name: 2 Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Jinan, 250012, China – name: 4 Department of General Surgery, Qilu Hospital of Shandong University, Jinan, 250012, China – name: 3 Department of Endocrine and Metabolism, Qilu Hospital of Shandong University, Jinan, 250012, China – name: 1 Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, 250013, China |
| Author_xml | – sequence: 1 givenname: Yali surname: Han fullname: Han, Yali organization: Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, 250013, China – sequence: 2 givenname: Qichao surname: Qi fullname: Qi, Qichao organization: Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Jinan, 250012, China – sequence: 3 givenname: Qin surname: He fullname: He, Qin organization: Department of Endocrine and Metabolism, Qilu Hospital of Shandong University, Jinan, 250012, China – sequence: 4 givenname: Meili surname: Sun fullname: Sun, Meili organization: Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, 250013, China – sequence: 5 givenname: Shuyun surname: Wang fullname: Wang, Shuyun organization: Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, 250013, China – sequence: 6 givenname: Guanzhou surname: Zhou fullname: Zhou, Guanzhou organization: Department of General Surgery, Qilu Hospital of Shandong University, Jinan, 250012, China – sequence: 7 givenname: Yuping surname: Sun fullname: Sun, Yuping organization: Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, 250013, China |
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| Cites_doi | 10.1186/s12885-016-2210-8 10.3322/caac.21262 10.1038/ng.2561 10.1093/jnci/djt018 10.1002/ijc.24986 10.18632/oncotarget.6324 10.1007/s12672-014-0196-8 10.1007/s13277-014-1758-7 10.1038/ng.2563 10.1038/nature05610 10.1038/ng1696 10.1146/annurev-med-100708-204735 10.1007/s00432-015-2038-7 10.1093/carcin/bgt185 10.1038/ng.287 10.1038/nature11017 10.1073/pnas.1009687108 10.1016/j.molmed.2015.02.007 10.1016/j.cell.2012.04.024 10.1038/ng.3041 10.1038/nrg2809 10.1038/ng.2955 10.1038/ncomms11375 10.1093/hmg/ddv251 10.1038/ng.2701 10.1371/journal.pgen.0030063 10.1038/ng1562 10.1038/ng.1049 10.1093/hmg/dds513 10.1016/S0168-9525(03)00054-4 10.1038/nature11881 10.4049/jimmunol.1501504 10.1038/nrc2840 10.1038/ng.2702 |
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| Keywords | breast cancer APOBEC3 cancer susceptibility copy number variation |
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| SubjectTerms | APOBEC Deaminases Breast Neoplasms - genetics Cytidine Deaminase Cytosine Deaminase - genetics DNA Copy Number Variations Female Gene Deletion Genetic Predisposition to Disease Genotype Humans INDEL Mutation Odds Ratio Publication Bias Research Paper Risk |
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| Title | APOBEC3 deletion increases the risk of breast cancer: a meta-analysis |
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