APOBEC3 deletion increases the risk of breast cancer: a meta-analysis

• Published in: Oncotarget Vol. 7; no. 46; pp. 74979 - 74986
• Main Authors: Han, Yali, Qi, Qichao, He, Qin, Sun, Meili, Wang, Shuyun, Zhou, Guanzhou, Sun, Yuping
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 15.11.2016
• Subjects: APOBEC Deaminases; Breast Neoplasms - genetics; Cytidine Deaminase; Cytosine Deaminase - genetics; DNA Copy Number Variations; Female; Gene Deletion; Genetic Predisposition to Disease; Genotype; Humans; INDEL Mutation; Odds Ratio; Publication Bias; Research Paper; Risk; breast cancer; APOBEC3; cancer susceptibility; copy number variation
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.11792

Recently, a deletion in the human apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) gene cluster has been associated with a modest increased risk of breast cancer, but studies yielded inconsistent results. Therefore we performed a meta-analysis to derive a more precise conclusion. Six studies including 18241 subjects were identified by searching PubMed and Embase databases from inception to April 2016. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were evaluated under allele contrast, dominant, recessive, homozygous, and heterozygous models. All the analyses suggested a correlation of APOBEC3 deletion with increased breast cancer risk (D vs I: OR = 1.29, 95% CI = 1.23-1.36; D/D+I/D vs I/I: OR = 1.34, 95% CI = 1.26-1.43; D/D vs I/D+ I/I: OR = 1.51, 95% CI = 1.36-1.68; D/D vs I/I: OR = 1.75, 95% CI= 1.56-1.95; I/D vs I/I: OR = 1.28, 95% CI = 1.19-1.36). Stratified analysis by ethnicity showed that the relationship is stronger and more stable in Asians. In summary, our current work indicated that APOBEC3 copy number variations might have a good screening accuracy for breast cancer.