Contribution of 5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase Genotypes to Colorectal Cancer in Taiwan

• Published in: Anticancer research Vol. 42; no. 5; pp. 2375 - 2382
• Main Authors: WU, MING-HSIEN, CHEN, CHAO-HSUAN, CHEN, CHOU-PIN, HUANG, TAI-LIN, YUEH, TE-CHENG, WANG, ZHI-HONG, TSAI, CHIA-WEN, PEI, JEN-SHENG, MONG, MEI-CHIN, YANG, YA-CHEN, BAU, DA-TIAN, CHANG, WEN-SHIN
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.05.2022
• Subjects: Alcohol use; Cancer; Case-Control Studies; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; DNA methylation; DNA repair; Enzymes; Ferredoxin-NADP Reductase - genetics; Folic acid; Frequency analysis; Gene frequency; Genetic Predisposition to Disease; Genotype; Genotype & phenotype; Genotypes; Habits; Health risks; Homocysteine; Homocysteine S-Methyltransferase - genetics; Humans; Metabolism; Methyltransferase; Mortality; Reductases; Risk; Smoking; Taiwan - epidemiology; Tetrahydrofolates; Trends; Vitamin B; Taiwan; polymorphism; MTRR; Colorectal cancer; Taiwan; genotype
• ISSN: 0250-7005; 1791-7530; 1791-7530
• DOI: 10.21873/anticanres.15716

5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) is responsible for folate metabolism, and we aimed to investigate its genetic role in colorectal cancer (CRC) among Taiwanese. A total of 362 cases and 362 controls were recruited and their MTRR rs1801394 (A66G) and rs1532268 (C524T) genotypes were examined. The behavioral factors and clinicalpathological factors were also analyzed. MTRR rs1801394 genotypes were associated with CRC risk (p for trend=0.0087). In detail, G/G genotype was associated with lower risk (p=0.0049, OR=0.39, 95%CI=0.20-0.76). As for allelic frequency analysis, G allele was also associated with decreased CRC risk (p=0.0026, OR=0.68, 95%CI=0.53-0.88). There was no significant association as for MTRR rs1532268. Among non-smokers and non-alcohol drinkers, those with G/G genotype were at 0.38- and 0.46-fold odds of having CRC. There were no significant protective effects among smokers or alcohol drinkers. MTRR rs1801394 GG genotype can be a protective marker for CRC risk in Taiwan.