The role of visfatin and omentin-1 gene polymorphism in pancreatic ductal adenocarcinoma (PDAC)

• Published in: Molecular biology reports Vol. 52; no. 1; p. 718
• Main Authors: Badr, Eman AE, Salem, Waheed M., Mekhail, Yostena, Rashed, Hager Mohamed
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 16.07.2025; Springer Nature B.V
• Subjects: Adenocarcinoma; Aged; Alleles; Animal Anatomy; Animal Biochemistry; Biomarkers; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Biomedical and Life Sciences; Body fat; Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - pathology; Case-Control Studies; Cytokines - blood; Cytokines - genetics; Disease; Female; Gene polymorphism; Genetic Predisposition to Disease - genetics; Genotype; Genotyping; GPI-Linked Proteins - blood; GPI-Linked Proteins - genetics; Histology; Humans; Lectins - blood; Lectins - genetics; Life Sciences; Male; Medical laboratories; Metabolism; Metastases; Metastasis; Middle Aged; Morphology; Mutation; Nicotinamide Phosphoribosyltransferase - blood; Nicotinamide Phosphoribosyltransferase - genetics; Nuclear medicine; Oncology; Original Article; Pancreatic cancer; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Patients; Polymorphism; Polymorphism, Single Nucleotide - genetics; Prognosis; Serum levels; Survival; Tumor markers; Tumors; United States > US; China; Serum omentin-1; rs2274907; Serum visfatin; rs4730153; Pancreatic cancer
• ISSN: 0301-4851; 1573-4978; 1573-4978
• DOI: 10.1007/s11033-025-10747-1

Background Pancreatic ductal adenocarcinoma is a highly aggressive digestive system tumor with a poor prognosis. It is characterized by aggressive features and non-specific early symptoms, often leading to detection only after metastasis has occurred. Objectives To investigate the role of visfatin rs4730153 and omentin-1 rs2274907 gene polymorphisms in susceptibility to pancreatic cancer, while evaluating their serum levels and correlating these levels with clinical, laboratory, and pathological data. Subjects and methods This study involved 192 participants, including 96 native pancreatic cancer patients with confirmed histopathological examinations and 96 age- and gender-matched controls. All individuals underwent a comprehensive medical history assessment, physical examination, and ultrasound imaging. Serum levels of visfatin, omentin-1, and tumor markers were measured using ELISA techniques. Genotyping of visfatin (rs4730153) and omentin (rs2274907) polymorphisms was conducted using quantitative fluorescent PCR. Results The GG genotype and G allele of rs4730153 were significantly more prevalent in the patient group, with odds ratios of 4.154 and 1.711, respectively. Additionally, vascular invasion, poor survival, and a progressive disease course were significantly more common in the AG and GG genotypes. The distribution of omentin-1 rs2274907 indicated that higher serum visfatin levels, larger tumor sizes, vascular invasion, metastasis, poor survival, and lower serum omentin-1 levels were significantly more prevalent in the AT and TT genotypes. Conclusion The visfatin rs4730153 gene polymorphism is associated with susceptibility to pancreatic cancer, vascular invasion, a progressive disease course, and poor survival outcomes. In contrast, the omentin-1 rs2274907 polymorphism is linked to tumor size, vascular invasion, metastasis, and overall survival.