Safety of laparoscopic surgery for ovarian tissue cryopreservation in pediatric patients

• Published in: International journal of clinical oncology Vol. 30; no. 6; pp. 1051 - 1059
• Main Authors: Kondo, Haruhiro, Takae, Seido, Furuta, Shigeyuki, Sakamoto, Miki, Obayashi, Juma, Keino, Dai, Nakamura, Kentaro, Tanaka, Kunihide, Kawaguchi, Takuya, Mori, Mika, Furuya, Natsumi, Nishioka, Mikiko, Suzuki-Takahashi, Yuki, Nagae, Chiai, Sugishita, Yodo, Horage-Okutsu, Yuki, Mori, Tetsuya, Shimizu, Naoki, Kitagawa, Hiroaki, Suzuki, Nao
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.06.2025; Springer Nature B.V
• Subjects: Adolescent; Blood; Body mass index; Cancer Research; Chemotherapy; Child; Child, Preschool; Children; Comorbidity; Cryopreservation; Cryopreservation - methods; Disease; Electronic medical records; Female; Fertility; Fertility Preservation - methods; Humans; Infant; Infant, Newborn; Japan; JSCO Board of Directors Series; Laparoscopy; Laparoscopy - adverse effects; Laparoscopy - methods; Leukocytes; Medicine; Medicine & Public Health; Oncology; Ovariectomy; Ovariectomy - adverse effects; Ovariectomy - methods; Ovaries; Ovary - surgery; Patients; Pediatrics; Radiation therapy; Retrospective Studies; Surgery; Surgical Oncology; Surgical outcomes; Japan; Child cancer; Laparoscopic surgery; Ovarian tissue cryopreservation; Fertility preservation
• ISSN: 1341-9625; 1437-7772; 1437-7772
• DOI: 10.1007/s10147-025-02757-7

Background Ovarian tissue cryopreservation (OTC) is recognized as the only option for fertility preservation in children. However, surgery for OTC in pediatric patients carries risks differing significantly from those in adults, and little is known about its safety. As a representative fertility preservation center in Japan, we investigated safety and feasibility of surgery for OTC in children. Methods The survey period was from November 2015 to November 2024. Data were collected retrospectively from the electronic medical records of 0- to 17-year-old girls who underwent OTC at our hospital. Age, primary disease, height, weight, comorbidities, operation time and blood loss, surgical complications, and changes in blood data of subjects were verified. Results Mean age of the 110 patients was 8.9 ± 5.0 years. Of the patients, 89 (80.9%) had malignant diseases, with leukemia ( n  = 21. 19.1%) as the most common underlying disease. Twenty patients (18.1%) had recurrent disease and 84 (76.4%) were undergoing surgery during chemotherapy and/or radiotherapy. Mean body mass index was 17.0 kg/m 2 , and some patients were thin and had delayed physical development. Ninety-two patients (83.6%) showed low white blood cell counts immediately before surgery. Laparoscopic unilateral oophorectomy was performed in all cases, with an average operation time of 55.5 ± 14.3 min and an average blood loss of 2.9 ± 8.4 g. One patient (0.9%) developed fever as a surgical complication. Conclusions These results suggest that laparoscopic surgery for OTC in children can be performed safely with the cooperation of experts from multiple medical fields.