Anoikis-Related Genes Impact Prognosis and Tumor Microenvironment in Bladder Cancer
Anoikis tolerance is an important biological process of tumor colonization and metastasis outside the primary tumor. Recent research has progressively elucidated the function and underlying mechanisms of anoikis in the metastasis of various solid tumors. Nevertheless, the specific mechanisms of anoi...
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| Published in | Molecular biotechnology Vol. 67; no. 8; pp. 3268 - 3280 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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New York
Springer US
01.08.2025
Springer Nature B.V |
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| Online Access | Get full text |
| ISSN | 1073-6085 1559-0305 1559-0305 |
| DOI | 10.1007/s12033-024-01255-x |
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| Abstract | Anoikis tolerance is an important biological process of tumor colonization and metastasis outside the primary tumor. Recent research has progressively elucidated the function and underlying mechanisms of anoikis in the metastasis of various solid tumors. Nevertheless, the specific mechanisms of anoikis in bladder cancer and its consequent effects on the tumor immune microenvironment remain ambiguous. In this study, we developed an anoikis score based on five genes (ETV7, NGF, SCD, LAMC1, and CASP6) and categorized subjects into high and low-risk groups using the median score from the TCGA database. Our findings indicate that SCD enhances the proliferation of bladder cancer cells in vitro. Furthermore, integrating the anoikis score with clinicopathological features to construct a prognostic nomogram demonstrated precision in assessing patient outcomes. Immune cell analysis revealed elevated infiltration levels of Treg cells and M2 macrophages in the high anoikis score group, whereas CD8
+
T cell levels were reduced. This study highlights the importance of anoikis score in predicting patient prognosis, immune cell infiltration, and drug response, which may provide a treatment modality worth exploring in depth for the study of bladder cancer. |
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| AbstractList | Anoikis tolerance is an important biological process of tumor colonization and metastasis outside the primary tumor. Recent research has progressively elucidated the function and underlying mechanisms of anoikis in the metastasis of various solid tumors. Nevertheless, the specific mechanisms of anoikis in bladder cancer and its consequent effects on the tumor immune microenvironment remain ambiguous. In this study, we developed an anoikis score based on five genes (ETV7, NGF, SCD, LAMC1, and CASP6) and categorized subjects into high and low-risk groups using the median score from the TCGA database. Our findings indicate that SCD enhances the proliferation of bladder cancer cells in vitro. Furthermore, integrating the anoikis score with clinicopathological features to construct a prognostic nomogram demonstrated precision in assessing patient outcomes. Immune cell analysis revealed elevated infiltration levels of Treg cells and M2 macrophages in the high anoikis score group, whereas CD8+ T cell levels were reduced. This study highlights the importance of anoikis score in predicting patient prognosis, immune cell infiltration, and drug response, which may provide a treatment modality worth exploring in depth for the study of bladder cancer. Anoikis tolerance is an important biological process of tumor colonization and metastasis outside the primary tumor. Recent research has progressively elucidated the function and underlying mechanisms of anoikis in the metastasis of various solid tumors. Nevertheless, the specific mechanisms of anoikis in bladder cancer and its consequent effects on the tumor immune microenvironment remain ambiguous. In this study, we developed an anoikis score based on five genes (ETV7, NGF, SCD, LAMC1, and CASP6) and categorized subjects into high and low-risk groups using the median score from the TCGA database. Our findings indicate that SCD enhances the proliferation of bladder cancer cells in vitro. Furthermore, integrating the anoikis score with clinicopathological features to construct a prognostic nomogram demonstrated precision in assessing patient outcomes. Immune cell analysis revealed elevated infiltration levels of Treg cells and M2 macrophages in the high anoikis score group, whereas CD8 + T cell levels were reduced. This study highlights the importance of anoikis score in predicting patient prognosis, immune cell infiltration, and drug response, which may provide a treatment modality worth exploring in depth for the study of bladder cancer. Anoikis tolerance is an important biological process of tumor colonization and metastasis outside the primary tumor. Recent research has progressively elucidated the function and underlying mechanisms of anoikis in the metastasis of various solid tumors. Nevertheless, the specific mechanisms of anoikis in bladder cancer and its consequent effects on the tumor immune microenvironment remain ambiguous. In this study, we developed an anoikis score based on five genes (ETV7, NGF, SCD, LAMC1, and CASP6) and categorized subjects into high and low-risk groups using the median score from the TCGA database. Our findings indicate that SCD enhances the proliferation of bladder cancer cells in vitro. Furthermore, integrating the anoikis score with clinicopathological features to construct a prognostic nomogram demonstrated precision in assessing patient outcomes. Immune cell analysis revealed elevated infiltration levels of Treg cells and M2 macrophages in the high anoikis score group, whereas CD8 T cell levels were reduced. This study highlights the importance of anoikis score in predicting patient prognosis, immune cell infiltration, and drug response, which may provide a treatment modality worth exploring in depth for the study of bladder cancer. Anoikis tolerance is an important biological process of tumor colonization and metastasis outside the primary tumor. Recent research has progressively elucidated the function and underlying mechanisms of anoikis in the metastasis of various solid tumors. Nevertheless, the specific mechanisms of anoikis in bladder cancer and its consequent effects on the tumor immune microenvironment remain ambiguous. In this study, we developed an anoikis score based on five genes (ETV7, NGF, SCD, LAMC1, and CASP6) and categorized subjects into high and low-risk groups using the median score from the TCGA database. Our findings indicate that SCD enhances the proliferation of bladder cancer cells in vitro. Furthermore, integrating the anoikis score with clinicopathological features to construct a prognostic nomogram demonstrated precision in assessing patient outcomes. Immune cell analysis revealed elevated infiltration levels of Treg cells and M2 macrophages in the high anoikis score group, whereas CD8+ T cell levels were reduced. This study highlights the importance of anoikis score in predicting patient prognosis, immune cell infiltration, and drug response, which may provide a treatment modality worth exploring in depth for the study of bladder cancer.Anoikis tolerance is an important biological process of tumor colonization and metastasis outside the primary tumor. Recent research has progressively elucidated the function and underlying mechanisms of anoikis in the metastasis of various solid tumors. Nevertheless, the specific mechanisms of anoikis in bladder cancer and its consequent effects on the tumor immune microenvironment remain ambiguous. In this study, we developed an anoikis score based on five genes (ETV7, NGF, SCD, LAMC1, and CASP6) and categorized subjects into high and low-risk groups using the median score from the TCGA database. Our findings indicate that SCD enhances the proliferation of bladder cancer cells in vitro. Furthermore, integrating the anoikis score with clinicopathological features to construct a prognostic nomogram demonstrated precision in assessing patient outcomes. Immune cell analysis revealed elevated infiltration levels of Treg cells and M2 macrophages in the high anoikis score group, whereas CD8+ T cell levels were reduced. This study highlights the importance of anoikis score in predicting patient prognosis, immune cell infiltration, and drug response, which may provide a treatment modality worth exploring in depth for the study of bladder cancer. |
| Author | Chen, Shaojun Wang, Longsheng Qu, Shanna Zhang, Tao |
| Author_xml | – sequence: 1 givenname: Tao surname: Zhang fullname: Zhang, Tao organization: Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Cheeloo College of Medicine, Shandong University – sequence: 2 givenname: Shaojun surname: Chen fullname: Chen, Shaojun organization: Department of Urology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Cheeloo College of Medicine, Shandong University – sequence: 3 givenname: Shanna surname: Qu fullname: Qu, Shanna organization: Department of Urology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Cheeloo College of Medicine, Shandong University – sequence: 4 givenname: Longsheng orcidid: 0000-0003-1050-933X surname: Wang fullname: Wang, Longsheng email: wls0534@163.com organization: Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Cheeloo College of Medicine, Shandong University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39172330$$D View this record in MEDLINE/PubMed |
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| Keywords | Immune microenvironment Drug response Anoikis Bladder cancer |
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| SubjectTerms | Aged Anoikis Anoikis - genetics Apoptosis Biochemistry Biological activity Biological Techniques Biomarkers, Tumor - genetics Biotechnology Bladder Bladder cancer Cancer CD8 antigen Cell Biology Cell cycle Cell Line, Tumor Cell proliferation Chemistry Chemistry and Materials Science Correlation analysis Female Flow cytometry Gene Expression Regulation, Neoplastic Genes Human Genetics Humans Immune system Immunological tolerance Infiltration Kidney cancer Lymphocytes Lymphocytes T Macrophages Male Medical prognosis Metastases Metastasis Middle Aged Nerve growth factor Nerve Growth Factor - genetics Nomograms Original Paper Prognosis Prostate cancer Protein Science Risk groups Solid tumors Tumor microenvironment Tumor Microenvironment - genetics Tumors Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - immunology Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - pathology |
| Title | Anoikis-Related Genes Impact Prognosis and Tumor Microenvironment in Bladder Cancer |
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