Mucosal Immunity and acute viral gastroenteritis The example rotavirus

Acute gastroenteritis is a major killer of the very young worldwide. Rotavirus is the most common intestinal virus, causing acute gastroenteritis and extra-intestinal complications especially in young and chronically ill subjects. As early as 1991, the WHO recommended as high priority the developmen...

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Bibliographic Details
Published inHuman vaccines & immunotherapeutics Vol. 10; no. 7; pp. 2112 - 2114
Main Author Rose, Markus A
Format Journal Article
LanguageEnglish
Published Taylor & Francis 01.07.2014
Landes Bioscience
Subjects
diarrhea
elderly
gastroenteritis
immunization
mucosal
Review
rota-virus
young
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ISSN2164-5515
2164-554X
DOI10.4161/hv.29605

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Summary:Acute gastroenteritis is a major killer of the very young worldwide. Rotavirus is the most common intestinal virus, causing acute gastroenteritis and extra-intestinal complications especially in young and chronically ill subjects. As early as 1991, the WHO recommended as high priority the development of a vaccine against rotavirus, the major pathogen causing enteric infections. Since the introduction of rotavirus vaccines for infant immunization programmes in different parts of the world in 2006, vaccination against rotavirus has resulted in substantial declines in severe gastroenteritis. The oral rotavirus vaccines RotaTeq ® and Rotarix ® are excellent examples for their unique features and principles of mucosal immunization. We elaborate on rotavirus immunity and the success of rotavirus vaccination and aspects also beyond infants' acute gastroenteritis.
ISSN:2164-5515
2164-554X
DOI:10.4161/hv.29605