Colorectal cancer clocks in on TIME

Immune responses are subject to circadian regulation, but circadian effects on antitumor immune response are unknown. Disruption of intestinal circadian rhythms is now shown to promote immunosuppression by altering the tumor immune microenvironment (TIME) in colorectal cancer.

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Bibliographic Details
Published inNature immunology Vol. 25; no. 7; pp. 1133 - 1135
Main Authors Knudsen-Clark, Amelia M., Altman, Brian J.
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.07.2024
Nature Publishing Group
Subjects
631/250/580
631/45
631/67/1059/2325
Antitumor activity
Biomedical and Life Sciences
Biomedicine
Cancer therapies
Circadian rhythm
Circadian rhythms
Colorectal cancer
Colorectal carcinoma
Cytokines
Immune response
Immunology
Immunosuppression
Infectious Diseases
Investigations
Lymphocytes
Microenvironments
Neutrophils
News & Views
news-and-views
Spleen
Tumorigenesis
Online AccessGet full text
ISSN1529-2908
1529-2916
1529-2916
DOI10.1038/s41590-024-01874-1

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Summary:Immune responses are subject to circadian regulation, but circadian effects on antitumor immune response are unknown. Disruption of intestinal circadian rhythms is now shown to promote immunosuppression by altering the tumor immune microenvironment (TIME) in colorectal cancer.
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ISSN:1529-2908
1529-2916
1529-2916
DOI:10.1038/s41590-024-01874-1